Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice

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dc.citation.firstpage1386
dc.citation.issueNumber4
dc.citation.journalTitleACS Biomaterials Science & Engineering
dc.citation.lastpage1396
dc.citation.volumeNumber4
dc.contributor.authorCarrejo, Nicole C.
dc.contributor.authorMoore, Amanda N.
dc.contributor.authorLopez Silva, Tania L.
dc.contributor.authorLeach, David G.
dc.contributor.authorLi, I-Che
dc.contributor.authorWalker, Douglas R.
dc.contributor.authorHartgerink, Jeffrey D.
dc.date.accessioned2019-11-22T16:19:57Z
dc.date.available2019-11-22T16:19:57Z
dc.date.issued2018
dc.description.abstractIn vivo, multidomain peptide (MDP) hydrogels undergo rapid cell infiltration and elicit a mild inflammatory response which promotes angiogenesis. Over time, the nanofibers are degraded and a natural collagen-based extracellular matrix is produced remodeling the artificial material into natural tissue. These properties make MDPs particularly well suited for applications in regeneration. In this work, we test the regenerative potential of MDP hydrogels in a diabetic wound healing model. When applied to full-thickness dermal wounds in genetically diabetic mice, the MDP hydrogel resulted in significantly accelerated wound healing compared to a clinically used hydrogel, as well as a control buffer. Treatment with the MDP hydrogel resulted in wound closure in 14 days, formation of thick granulation tissue including dense vascularization, innervation, and hair follicle regeneration. This suggests the MDP hydrogel could be an attractive choice for treatment of wounds in diabetic patients.
dc.identifier.citationCarrejo, Nicole C., Moore, Amanda N., Lopez Silva, Tania L., et al.. "Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice." <i>ACS Biomaterials Science & Engineering,</i> 4, no. 4 (2018) American Chemical Society: 1386-1396. https://doi.org/10.1021/acsbiomaterials.8b00031.
dc.identifier.digitalnihms952101
dc.identifier.doihttps://doi.org/10.1021/acsbiomaterials.8b00031
dc.identifier.urihttps://hdl.handle.net/1911/107722
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society
dc.subject.keywordpeptide
dc.subject.keywordhydrogel
dc.subject.keywordself-assembly
dc.subject.keyworddiabetic ulcer
dc.subject.keywordwound healing
dc.titleMultidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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