Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice

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dc.citation.firstpage1386en_US
dc.citation.issueNumber4en_US
dc.citation.journalTitleACS Biomaterials Science & Engineeringen_US
dc.citation.lastpage1396en_US
dc.citation.volumeNumber4en_US
dc.contributor.authorCarrejo, Nicole C.en_US
dc.contributor.authorMoore, Amanda N.en_US
dc.contributor.authorLopez Silva, Tania L.en_US
dc.contributor.authorLeach, David G.en_US
dc.contributor.authorLi, I-Cheen_US
dc.contributor.authorWalker, Douglas R.en_US
dc.contributor.authorHartgerink, Jeffrey D.en_US
dc.date.accessioned2019-11-22T16:19:57Zen_US
dc.date.available2019-11-22T16:19:57Zen_US
dc.date.issued2018en_US
dc.description.abstractIn vivo, multidomain peptide (MDP) hydrogels undergo rapid cell infiltration and elicit a mild inflammatory response which promotes angiogenesis. Over time, the nanofibers are degraded and a natural collagen-based extracellular matrix is produced remodeling the artificial material into natural tissue. These properties make MDPs particularly well suited for applications in regeneration. In this work, we test the regenerative potential of MDP hydrogels in a diabetic wound healing model. When applied to full-thickness dermal wounds in genetically diabetic mice, the MDP hydrogel resulted in significantly accelerated wound healing compared to a clinically used hydrogel, as well as a control buffer. Treatment with the MDP hydrogel resulted in wound closure in 14 days, formation of thick granulation tissue including dense vascularization, innervation, and hair follicle regeneration. This suggests the MDP hydrogel could be an attractive choice for treatment of wounds in diabetic patients.en_US
dc.identifier.citationCarrejo, Nicole C., Moore, Amanda N., Lopez Silva, Tania L., et al.. "Multidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Mice." <i>ACS Biomaterials Science & Engineering,</i> 4, no. 4 (2018) American Chemical Society: 1386-1396. https://doi.org/10.1021/acsbiomaterials.8b00031.en_US
dc.identifier.digitalnihms952101en_US
dc.identifier.doihttps://doi.org/10.1021/acsbiomaterials.8b00031en_US
dc.identifier.urihttps://hdl.handle.net/1911/107722en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Societyen_US
dc.subject.keywordpeptideen_US
dc.subject.keywordhydrogelen_US
dc.subject.keywordself-assemblyen_US
dc.subject.keyworddiabetic ulceren_US
dc.subject.keywordwound healingen_US
dc.titleMultidomain Peptide Hydrogel Accelerates Healing of Full-Thickness Wounds in Diabetic Miceen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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