Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison

dc.citation.journalTitleBiomedical Optics Expressen_US
dc.contributor.authorFouad, Anthonyen_US
dc.contributor.authorPfefer, T. Joshuaen_US
dc.contributor.authorChen, Chao-Weien_US
dc.contributor.authorGong, Weien_US
dc.contributor.authorAgrawal, Ananten_US
dc.contributor.authorTomlins, Peter H.en_US
dc.contributor.authorWoolliams, Peter D.en_US
dc.contributor.authorDrezek, Rebekah A.en_US
dc.contributor.authorChen, Yuen_US
dc.description.abstractPoint spread function (PSF) phantoms based on unstructured distributions of sub-resolution particles in a transparent matrix have been demonstrated as a useful tool for evaluating resolution and its spatial variation across image volumes in optical coherence tomography (OCT) systems. Measurements based on PSF phantoms have the potential to become a standard test method for consistent, objective and quantitative inter-comparison of OCT system performance. Towards this end, we have evaluated three PSF phantoms and investigated their ability to compare the performance of four OCT systems. The phantoms are based on 260-nm-diameter gold nanoshells, 400-nm-diameter iron oxide particles and 1.5-micron-diameter silica particles. The OCT systems included spectral-domain and swept source systems in free-beam geometries as well as a time-domain system in both free-beam and fiberoptic probe geometries. Results indicated that iron oxide particles and gold nanoshells were most effective for measuring spatial variations in the magnitude and shape of PSFs across the image volume. The intensity of individual particles was also used to evaluate spatial variations in signal intensity uniformity. Significant system-to-system differences in resolution and signal intensity and their spatial variation were readily quantified. The phantoms proved useful for identification and characterization of irregularities such as astigmatism. Our multi-system results provide evidence of the practical utility of PSF-phantom-based test methods for quantitative inter-comparison of OCT system resolution and signal uniformity.en_US
dc.identifier.citationFouad, Anthony, Pfefer, T. Joshua, Chen, Chao-Wei, et al.. "Variations in optical coherence tomography resolution and uniformity: a multi-system performance comparison." <i>Biomedical Optics Express,</i> 5, no. 7 (2014) Optical Society of America: 2066-2081.
dc.publisherOptical Society of America
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
dc.titleVariations in optical coherence tomography resolution and uniformity: a multi-system performance comparisonen_US
dc.typeJournal articleen_US
dc.type.publicationpublisher versionen_US
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
3.38 MB
Adobe Portable Document Format