Roadmap for the multiscale coupling of biochemical and mechanical signals during development

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dc.citation.articleNumber41501
dc.citation.issueNumber4
dc.citation.journalTitlePhysical Biology
dc.citation.volumeNumber18
dc.contributor.authorLenne, Pierre-François
dc.contributor.authorMunro, Edwin
dc.contributor.authorHeemskerk, Idse
dc.contributor.authorWarmflash, Aryeh
dc.contributor.authorBocanegra-Moreno, Laura
dc.contributor.authorKishi, Kasumi
dc.contributor.authorKicheva, Anna
dc.contributor.authorLong, Yuchen
dc.contributor.authorFruleux, Antoine
dc.contributor.authorBoudaoud, Arezki
dc.contributor.authorSaunders, Timothy E.
dc.contributor.authorCaldarelli, Paolo
dc.contributor.authorMichaut, Arthur
dc.contributor.authorGros, Jerome
dc.contributor.authorMaroudas-Sacks, Yonit
dc.contributor.authorKeren, Kinneret
dc.contributor.authorHannezo, Edouard
dc.contributor.authorGartner, Zev J.
dc.contributor.authorStormo, Benjamin
dc.contributor.authorGladfelter, Amy
dc.contributor.authorRodrigues, Alan
dc.contributor.authorShyer, Amy
dc.contributor.authorMinc, Nicolas
dc.contributor.authorMaître, Jean-Léon
dc.contributor.authorTalia, Stefano Di
dc.contributor.authorKhamaisi, Bassma
dc.contributor.authorSprinzak, David
dc.contributor.authorTlili, Sham
dc.date.accessioned2021-05-07T19:23:44Z
dc.date.available2021-05-07T19:23:44Z
dc.date.issued2021
dc.description.abstractThe way in which interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image analysis have greatly enhanced our ability to observe and quantify spatiotemporal patterns of signalling, force generation, deformation, and flow in living cells and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation are allowing us to perturb the underlying machinery that generates these patterns in increasingly sophisticated ways. Rapid advances in theory and computing have made it possible to construct predictive models that describe how cell and tissue organization and dynamics emerge from the local coupling of biochemistry and mechanics. Together, these advances have opened up a wealth of new opportunities to explore how mechanochemical patterning shapes organismal development. In this roadmap, we present a series of forward-looking case studies on mechanochemical patterning in development, written by scientists working at the interface between the physical and biological sciences, and covering a wide range of spatial and temporal scales, organisms, and modes of development. Together, these contributions highlight the many ways in which the dynamic coupling of mechanics and biochemistry shapes biological dynamics: from mechanoenzymes that sense force to tune their activity and motor output, to collectives of cells in tissues that flow and redistribute biochemical signals during development.
dc.identifier.citationLenne, Pierre-François, Munro, Edwin, Heemskerk, Idse, et al.. "Roadmap for the multiscale coupling of biochemical and mechanical signals during development." <i>Physical Biology,</i> 18, no. 4 (2021) IOP Publishing: https://doi.org/10.1088/1478-3975/abd0db.
dc.identifier.digitalLenne_2021
dc.identifier.doihttps://doi.org/10.1088/1478-3975/abd0db
dc.identifier.urihttps://hdl.handle.net/1911/110491
dc.language.isoeng
dc.publisherIOP Publishing
dc.rightsOriginal content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleRoadmap for the multiscale coupling of biochemical and mechanical signals during development
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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