Roadmap for the multiscale coupling of biochemical and mechanical signals during development

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dc.citation.articleNumber41501en_US
dc.citation.issueNumber4en_US
dc.citation.journalTitlePhysical Biologyen_US
dc.citation.volumeNumber18en_US
dc.contributor.authorLenne, Pierre-Françoisen_US
dc.contributor.authorMunro, Edwinen_US
dc.contributor.authorHeemskerk, Idseen_US
dc.contributor.authorWarmflash, Aryehen_US
dc.contributor.authorBocanegra-Moreno, Lauraen_US
dc.contributor.authorKishi, Kasumien_US
dc.contributor.authorKicheva, Annaen_US
dc.contributor.authorLong, Yuchenen_US
dc.contributor.authorFruleux, Antoineen_US
dc.contributor.authorBoudaoud, Arezkien_US
dc.contributor.authorSaunders, Timothy E.en_US
dc.contributor.authorCaldarelli, Paoloen_US
dc.contributor.authorMichaut, Arthuren_US
dc.contributor.authorGros, Jeromeen_US
dc.contributor.authorMaroudas-Sacks, Yoniten_US
dc.contributor.authorKeren, Kinnereten_US
dc.contributor.authorHannezo, Edouarden_US
dc.contributor.authorGartner, Zev J.en_US
dc.contributor.authorStormo, Benjaminen_US
dc.contributor.authorGladfelter, Amyen_US
dc.contributor.authorRodrigues, Alanen_US
dc.contributor.authorShyer, Amyen_US
dc.contributor.authorMinc, Nicolasen_US
dc.contributor.authorMaître, Jean-Léonen_US
dc.contributor.authorTalia, Stefano Dien_US
dc.contributor.authorKhamaisi, Bassmaen_US
dc.contributor.authorSprinzak, Daviden_US
dc.contributor.authorTlili, Shamen_US
dc.date.accessioned2021-05-07T19:23:44Zen_US
dc.date.available2021-05-07T19:23:44Zen_US
dc.date.issued2021en_US
dc.description.abstractThe way in which interactions between mechanics and biochemistry lead to the emergence of complex cell and tissue organization is an old question that has recently attracted renewed interest from biologists, physicists, mathematicians and computer scientists. Rapid advances in optical physics, microscopy and computational image analysis have greatly enhanced our ability to observe and quantify spatiotemporal patterns of signalling, force generation, deformation, and flow in living cells and tissues. Powerful new tools for genetic, biophysical and optogenetic manipulation are allowing us to perturb the underlying machinery that generates these patterns in increasingly sophisticated ways. Rapid advances in theory and computing have made it possible to construct predictive models that describe how cell and tissue organization and dynamics emerge from the local coupling of biochemistry and mechanics. Together, these advances have opened up a wealth of new opportunities to explore how mechanochemical patterning shapes organismal development. In this roadmap, we present a series of forward-looking case studies on mechanochemical patterning in development, written by scientists working at the interface between the physical and biological sciences, and covering a wide range of spatial and temporal scales, organisms, and modes of development. Together, these contributions highlight the many ways in which the dynamic coupling of mechanics and biochemistry shapes biological dynamics: from mechanoenzymes that sense force to tune their activity and motor output, to collectives of cells in tissues that flow and redistribute biochemical signals during development.en_US
dc.identifier.citationLenne, Pierre-François, Munro, Edwin, Heemskerk, Idse, et al.. "Roadmap for the multiscale coupling of biochemical and mechanical signals during development." <i>Physical Biology,</i> 18, no. 4 (2021) IOP Publishing: https://doi.org/10.1088/1478-3975/abd0db.en_US
dc.identifier.digitalLenne_2021en_US
dc.identifier.doihttps://doi.org/10.1088/1478-3975/abd0dben_US
dc.identifier.urihttps://hdl.handle.net/1911/110491en_US
dc.language.isoengen_US
dc.publisherIOP Publishingen_US
dc.rightsOriginal content from this work may be used under the terms of the Creative Commons Attribution 4.0 licence. Any further distribution of this work must maintain attribution to the author(s) and the title of the work, journal citation and DOI.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleRoadmap for the multiscale coupling of biochemical and mechanical signals during developmenten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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