Advances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapy

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dc.citation.articleNumber170en_US
dc.citation.journalTitleFrontiers in Physiologyen_US
dc.citation.volumeNumber9en_US
dc.contributor.authorOzdemir-Kaynak, Elifen_US
dc.contributor.authorQutub, Amina A.en_US
dc.contributor.authorYesil-Celiktas, Ozlemen_US
dc.date.accessioned2018-11-15T17:16:12Zen_US
dc.date.available2018-11-15T17:16:12Zen_US
dc.date.issued2018en_US
dc.description.abstractThe most lethal form of brain cancer, glioblastoma multiforme, is characterized by rapid growth and invasion facilitated by cell migration and degradation of the extracellular matrix. Despite technological advances in surgery and radio-chemotherapy, glioblastoma remains largely resistant to treatment. New approaches to study glioblastoma and to design optimized therapies are greatly needed. One such approach harnesses computational modeling to support the design and delivery of glioblastoma treatment. In this paper, we critically summarize current glioblastoma therapy, with a focus on emerging nanomedicine and therapies that capitalize on cell-specific signaling in glioblastoma. We follow this summary by discussing computational modeling approaches focused on optimizing these emerging nanotherapeutics for brain cancer. We conclude by illustrating how mathematical analysis can be used to compare the delivery of a high potential anticancer molecule, delphinidin, in both free and nanoparticle loaded forms across the blood-brain barrier for glioblastoma.en_US
dc.identifier.citationOzdemir-Kaynak, Elif, Qutub, Amina A. and Yesil-Celiktas, Ozlem. "Advances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapy." <i>Frontiers in Physiology,</i> 9, (2018) Frontiers: https://doi.org/10.3389/fphys.2018.00170.en_US
dc.identifier.digitalfphys-09-00170en_US
dc.identifier.doihttps://doi.org/10.3389/fphys.2018.00170en_US
dc.identifier.urihttps://hdl.handle.net/1911/103342en_US
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keywordblood-brain barrier modelingen_US
dc.subject.keywordcytoscapeen_US
dc.subject.keyworddelphinidinen_US
dc.subject.keywordglioblastomaen_US
dc.subject.keywordnanoparticleen_US
dc.titleAdvances in Glioblastoma Multiforme Treatment: New Models for Nanoparticle Therapyen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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