Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance

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dc.citation.articleNumbere1005008en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitlePLoS Computational Biologyen_US
dc.citation.volumeNumber12en_US
dc.contributor.authorCamley, Brian A.en_US
dc.contributor.authorZimmermann, Julianeen_US
dc.contributor.authorLevine, Herberten_US
dc.contributor.authorRappel, Wouter-Janen_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2017-08-21T14:34:15Zen_US
dc.date.available2017-08-21T14:34:15Zen_US
dc.date.issued2016en_US
dc.description.abstractSingle eukaryotic cells commonly sense and follow chemical gradients, performing chemotaxis. Recent experiments and theories, however, show that even when single cells do not chemotax, clusters of cells may, if their interactions are regulated by the chemoattractant. We study this general mechanism of “collective guidance” computationally with models that integrate stochastic dynamics for individual cells with biochemical reactions within the cells, and diffusion of chemical signals between the cells. We show that if clusters of cells use the well-known local excitation, global inhibition (LEGI) mechanism to sense chemoattractant gradients, the speed of the cell cluster becomes non-monotonic in the cluster’s size—clusters either larger or smaller than an optimal size will have lower speed. We argue that the cell cluster speed is a crucial readout of how the cluster processes chemotactic signals; both amplification and adaptation will alter the behavior of cluster speed as a function of size. We also show that, contrary to the assumptions of earlier theories, collective guidance does not require persistent cell-cell contacts and strong short range adhesion. If cell-cell adhesion is absent, and the cluster cohesion is instead provided by a co-attraction mechanism, e.g. chemotaxis toward a secreted molecule, collective guidance may still function. However, new behaviors, such as cluster rotation, may also appear in this case. Co-attraction and adaptation allow for collective guidance that is robust to varying chemoattractant concentrations while not requiring strong cell-cell adhesion.en_US
dc.identifier.citationCamley, Brian A., Zimmermann, Juliane, Levine, Herbert, et al.. "Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance." <i>PLoS Computational Biology,</i> 12, no. 7 (2016) Public Library of Science: https://doi.org/10.1371/journal.pcbi.1005008.en_US
dc.identifier.digitalCollective_Signal_Processing_Cluster_Chemotaxisen_US
dc.identifier.doihttps://doi.org/10.1371/journal.pcbi.1005008en_US
dc.identifier.urihttps://hdl.handle.net/1911/97365en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleCollective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidanceen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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