As the severity and frequency of climate change–induced weather events increase and the effects of the COVID-19 pandemic on global trade persist, the health care sector remains vulnerable to supply chain disturbances internationally. Health care is a major contributor to greenhouse gas (GHG) emissions. Supply chains, including food and transportation, account for up to 80% of total health care–associated emissions in the US. Downstream consequences of GHG emissions from US health care are severe, resulting in losses of approximately 388 000 disability-adjusted life-years annually. In turn, health care systems are working to minimize GHG emissions and restructure supply chains.