The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis

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dc.citation.articleNumber603043en_US
dc.citation.journalTitleFrontiers in Cellular Neuroscienceen_US
dc.contributor.authorDerry, Paul J.en_US
dc.contributor.authorVo, Anh Tran Tramen_US
dc.contributor.authorGnanansekaran, Aswinien_US
dc.contributor.authorMitra, Joyen_US
dc.contributor.authorLiopo, Anton V.en_US
dc.contributor.authorHegde, Muralidhar L.en_US
dc.contributor.authorTsai, Ah-Limen_US
dc.contributor.authorTour, James M.en_US
dc.contributor.authorKent, Thomas A.en_US
dc.date.accessioned2021-02-08T18:37:55Zen_US
dc.date.available2021-02-08T18:37:55Zen_US
dc.date.issued2020en_US
dc.description.abstractIntracerebral hemorrhage (ICH) is a particularly devastating event both because of the direct injury from space-occupying blood to the sequelae of the brain exposed to free blood components from which it is normally protected. Not surprisingly, the usual metabolic and energy pathways are overwhelmed in this situation. In this review article, we detail the complexity of red blood cell degradation, the contribution of eryptosis leading to hemoglobin breakdown into its constituents, the participants in that process, and the points at which injury can be propagated such as elaboration of toxic radicals through the metabolism of the breakdown products. Two prominent products of this breakdown sequence, hemin, and iron, induce a variety of pathologies including free radical damage and DNA breakage, which appear to include events independent from typical oxidative DNA injury. As a result of this confluence of damaging elements, multiple pathways of injury, cell death, and survival are likely engaged including ferroptosis (which may be the same as oxytosis but viewed from a different perspective) and senescence, suggesting that targeting any single cause will likely not be a sufficient strategy to maximally improve outcome. Combination therapies in addition to safe methods to reduce blood burden should be pursued.en_US
dc.identifier.citationDerry, Paul J., Vo, Anh Tran Tram, Gnanansekaran, Aswini, et al.. "The Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosis." <i>Frontiers in Cellular Neuroscience,</i> (2020) Frontiers: https://doi.org/10.3389/fncel.2020.603043.en_US
dc.identifier.digitalfncel-14-603043en_US
dc.identifier.doihttps://doi.org/10.3389/fncel.2020.603043en_US
dc.identifier.urihttps://hdl.handle.net/1911/109818en_US
dc.language.isoengen_US
dc.publisherFrontiersen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleThe Chemical Basis of Intracerebral Hemorrhage and Cell Toxicity With Contributions From Eryptosis and Ferroptosisen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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