In vivo microscopy of hemozoin: towards a needle free diagnostic for malaria

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dc.citation.firstpage3462en_US
dc.citation.issueNumber9en_US
dc.citation.journalTitleBiomedical Optics Expressen_US
dc.citation.lastpage3474en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorBurnett, Jennifer L.en_US
dc.contributor.authorCarns, Jennifer L.en_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.orgBioengineeringen_US
dc.date.accessioned2015-09-24T18:13:01Zen_US
dc.date.available2015-09-24T18:13:01Zen_US
dc.date.issued2015en_US
dc.description.abstractClinical diagnosis of malaria suffers from poor specificity leading to overtreatment with antimalarial medications. Alternatives, like blood smear microscopy or antigen-based tests, require a blood sample. We investigate in vivo microscopy as a needle-free malaria diagnostic. Two optical signatures, birefringence and absorbance, of the endogenous malaria by-product hemozoin were evaluated as in vivo optical biomarkers. Hemozoin birefringence was difficult to detect in highly scattering tissue; however, hemozoin absorbance was observed in increasingly complex biological environments and detectable over a clinically-relevant range of parasitemia in vivo in a P. yoelii-infected mouse model of malaria.en_US
dc.identifier.citationBurnett, Jennifer L., Carns, Jennifer L. and Richards-Kortum, Rebecca. "In vivo microscopy of hemozoin: towards a needle free diagnostic for malaria." <i>Biomedical Optics Express,</i> 6, no. 9 (2015) The Optical Society: 3462-3474. http://dx.doi.org/10.1364/BOE.6.003462.en_US
dc.identifier.doihttp://dx.doi.org/10.1364/BOE.6.003462en_US
dc.identifier.urihttps://hdl.handle.net/1911/81716en_US
dc.language.isoengen_US
dc.publisherThe Optical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleIn vivo microscopy of hemozoin: towards a needle free diagnostic for malariaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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