The origin of bladder cancer from mucosal field effects

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dc.citation.articleNumber104551
dc.citation.issueNumber7
dc.citation.journalTitleiScience
dc.citation.volumeNumber25
dc.contributor.authorBondaruk, Jolanta
dc.contributor.authorJaksik, Roman
dc.contributor.authorWang, Ziqiao
dc.contributor.authorCogdell, David
dc.contributor.authorLee, Sangkyou
dc.contributor.authorChen, Yujie
dc.contributor.authorDinh, Khanh Ngoc
dc.contributor.authorMajewski, Tadeusz
dc.contributor.authorZhang, Li
dc.contributor.authorCao, Shaolong
dc.contributor.authorTian, Feng
dc.contributor.authorYao, Hui
dc.contributor.authorKuś, Paweł
dc.contributor.authorChen, Huiqin
dc.contributor.authorWeinstein, John N.
dc.contributor.authorNavai, Neema
dc.contributor.authorDinney, Colin
dc.contributor.authorGao, Jianjun
dc.contributor.authorTheodorescu, Dan
dc.contributor.authorLogothetis, Christopher
dc.contributor.authorGuo, Charles C.
dc.contributor.authorWang, Wenyi
dc.contributor.authorMcConkey, David
dc.contributor.authorWei, Peng
dc.contributor.authorKimmel, Marek
dc.contributor.authorCzerniak, Bogdan
dc.date.accessioned2022-08-04T14:53:10Z
dc.date.available2022-08-04T14:53:10Z
dc.date.issued2022
dc.description.abstractWhole-organ mapping was used to study molecular changes in the evolution of bladder cancer from field effects. We identified more than 100 dysregulated pathways, involving immunity, differentiation, and transformation, as initiators of carcinogenesis. Dysregulation of interleukins signified the involvement of inflammation in the incipient phases of the process. An aberrant methylation/expression of multiple HOX genes signified dysregulation of the differentiation program. We identified three types of mutations based on their geographic distribution. The most common were mutations restricted to individual mucosal samples that targeted uroprogenitor cells. Two types of mutations were associated with clonal expansion and involved large areas of mucosa. The α mutations occurred at low frequencies while the β mutations increased in frequency with disease progression. Modeling revealed that bladder carcinogenesis spans 10–15 years and can be divided into dormant and progressive phases. The progressive phase lasted 1-2 years and was driven by β mutations.
dc.identifier.citationBondaruk, Jolanta, Jaksik, Roman, Wang, Ziqiao, et al.. "The origin of bladder cancer from mucosal field effects." <i>iScience,</i> 25, no. 7 (2022) Cell Press: https://doi.org/10.1016/j.isci.2022.104551.
dc.identifier.digital1-s2-0-S2589004222008239-main
dc.identifier.doihttps://doi.org/10.1016/j.isci.2022.104551
dc.identifier.urihttps://hdl.handle.net/1911/112942
dc.language.isoeng
dc.publisherCell Press
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.titleThe origin of bladder cancer from mucosal field effects
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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