The origin of bladder cancer from mucosal field effects

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dc.citation.articleNumber104551en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleiScienceen_US
dc.citation.volumeNumber25en_US
dc.contributor.authorBondaruk, Jolantaen_US
dc.contributor.authorJaksik, Romanen_US
dc.contributor.authorWang, Ziqiaoen_US
dc.contributor.authorCogdell, Daviden_US
dc.contributor.authorLee, Sangkyouen_US
dc.contributor.authorChen, Yujieen_US
dc.contributor.authorDinh, Khanh Ngocen_US
dc.contributor.authorMajewski, Tadeuszen_US
dc.contributor.authorZhang, Lien_US
dc.contributor.authorCao, Shaolongen_US
dc.contributor.authorTian, Fengen_US
dc.contributor.authorYao, Huien_US
dc.contributor.authorKuś, Pawełen_US
dc.contributor.authorChen, Huiqinen_US
dc.contributor.authorWeinstein, John N.en_US
dc.contributor.authorNavai, Neemaen_US
dc.contributor.authorDinney, Colinen_US
dc.contributor.authorGao, Jianjunen_US
dc.contributor.authorTheodorescu, Danen_US
dc.contributor.authorLogothetis, Christopheren_US
dc.contributor.authorGuo, Charles C.en_US
dc.contributor.authorWang, Wenyien_US
dc.contributor.authorMcConkey, Daviden_US
dc.contributor.authorWei, Pengen_US
dc.contributor.authorKimmel, Mareken_US
dc.contributor.authorCzerniak, Bogdanen_US
dc.date.accessioned2022-08-04T14:53:10Zen_US
dc.date.available2022-08-04T14:53:10Zen_US
dc.date.issued2022en_US
dc.description.abstractWhole-organ mapping was used to study molecular changes in the evolution of bladder cancer from field effects. We identified more than 100 dysregulated pathways, involving immunity, differentiation, and transformation, as initiators of carcinogenesis. Dysregulation of interleukins signified the involvement of inflammation in the incipient phases of the process. An aberrant methylation/expression of multiple HOX genes signified dysregulation of the differentiation program. We identified three types of mutations based on their geographic distribution. The most common were mutations restricted to individual mucosal samples that targeted uroprogenitor cells. Two types of mutations were associated with clonal expansion and involved large areas of mucosa. The α mutations occurred at low frequencies while the β mutations increased in frequency with disease progression. Modeling revealed that bladder carcinogenesis spans 10–15 years and can be divided into dormant and progressive phases. The progressive phase lasted 1-2 years and was driven by β mutations.en_US
dc.identifier.citationBondaruk, Jolanta, Jaksik, Roman, Wang, Ziqiao, et al.. "The origin of bladder cancer from mucosal field effects." <i>iScience,</i> 25, no. 7 (2022) Cell Press: https://doi.org/10.1016/j.isci.2022.104551.en_US
dc.identifier.digital1-s2-0-S2589004222008239-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.isci.2022.104551en_US
dc.identifier.urihttps://hdl.handle.net/1911/112942en_US
dc.language.isoengen_US
dc.publisherCell Pressen_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.titleThe origin of bladder cancer from mucosal field effectsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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