Mechanisms of Hearing Loss after Blast Injury to the Ear

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dc.citation.firstpagee67618en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitlePLoS Oneen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorCho, Sung-Ilen_US
dc.contributor.authorGao, Simon S.en_US
dc.contributor.authorXia, Anpingen_US
dc.contributor.authorWang, Rosalieen_US
dc.contributor.authorSalles, Felipe T.en_US
dc.contributor.authorRaphael, Patrick D.en_US
dc.contributor.authorAbaya, Homeren_US
dc.contributor.authorWachtel, Jacquelineen_US
dc.contributor.authorBaek, Jongminen_US
dc.contributor.authorJacobs, Daviden_US
dc.contributor.authorRasband, Matthew N.en_US
dc.contributor.authorOghalai, John S.en_US
dc.date.accessioned2013-07-12T19:44:28Zen_US
dc.date.available2013-07-12T19:44:28Zen_US
dc.date.issued2013en_US
dc.description.abstractGiven the frequent use of improvised explosive devices (IEDs) around the world, the study of traumatic blast injuries is of increasing interest. The ear is the most common organ affected by blast injury because it is the bodyﾒs most sensitive pressure transducer. We fabricated a blast chamber to re-create blast profiles similar to that of IEDs and used it to develop a reproducible mouse model to study blast-induced hearing loss. The tympanic membrane was perforated in all mice after blast exposure and found to heal spontaneously. Micro-computed tomography demonstrated no evidence for middle ear or otic capsule injuries; however, the healed tympanic membrane was thickened. Auditory brainstem response and distortion product otoacoustic emission threshold shifts were found to be correlated with blast intensity. As well, these threshold shifts were larger than those found in control mice that underwent surgical perforation of their tympanic membranes, indicating cochlear trauma. Histological studies one week and three months after the blast demonstrated no disruption or damage to the intra-cochlear membranes. However, there was loss of outer hair cells (OHCs) within the basal turn of the cochlea and decreased spiral ganglion neurons (SGNs) and afferent nerve synapses. Using our mouse model that recapitulates human IED exposure, our results identify that the mechanisms underlying blast-induced hearing loss does not include gross membranous rupture as is commonly believed. Instead, there is both OHC and SGN loss that produce auditory dysfunction.en_US
dc.embargo.termsnoneen_US
dc.identifier.citationCho, Sung-Il, Gao, Simon S., Xia, Anping, et al.. "Mechanisms of Hearing Loss after Blast Injury to the Ear." <i>PLoS One,</i> 8, no. 7 (2013) Public Library of Science: e67618. https://doi.org/10.1371/journal.pone.0067618.en_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0067618en_US
dc.identifier.urihttps://hdl.handle.net/1911/71545en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleMechanisms of Hearing Loss after Blast Injury to the Earen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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