Theoretical Analysis of Microtubule Dynamics at All Times

Simple item page
dc.citation.firstpage13777en_US
dc.citation.issueNumber48en_US
dc.citation.journalTitleThe Journal of Physical Chemistry Ben_US
dc.citation.lastpage13784en_US
dc.citation.volumeNumber118en_US
dc.contributor.authorLi, Xinen_US
dc.contributor.authorKolomeisky, Anatoly B.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2014-12-10T15:47:10Zen_US
dc.date.available2014-12-10T15:47:10Zen_US
dc.date.issued2014en_US
dc.description.abstractMicrotubules are biopolymers consisting of tubulin dimer subunits. As a major component of cytoskeleton they are essential for supporting most important cellular processes such as cell division, signaling, intracellular transport and cell locomotion. The hydrolysis of guanosine triphosphate (GTP) molecules attached to each tubulin subunit supports the nonequilibrium nature of microtubule dynamics. One of the most spectacular properties of microtubules is their dynamic instability when their growth from continuous attachment of tubulin dimers stochastically alternates with periods of shrinking. Despite the critical importance of this process to all cellular activities, its mechanism remains not fully understood. We investigated theoretically microtubule dynamics at all times by analyzing explicitly temporal evolution of various length clusters of unhydrolyzed subunits. It is found that the dynamic behavior of microtubules depends strongly on initial conditions. Our theoretical findings provide a microscopic explanation for recent experiments which found that the frequency of catastrophes increases with the lifetime of microtubules. It is argued that most growing microtubule configurations cannot transit in one step into a shrinking state, leading to a complex overall temporal behavior. Theoretical calculations combined with Monte Carlo computer simulations are also directly compared with experimental observations, and good agreement is found.en_US
dc.identifier.citationLi, Xin and Kolomeisky, Anatoly B.. "Theoretical Analysis of Microtubule Dynamics at All Times." <i>The Journal of Physical Chemistry B,</i> 118, no. 48 (2014) American Chemical Society: 13777-13784. http://dx.doi.org/10.1021/jp507206f.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/jp507206fen_US
dc.identifier.urihttps://hdl.handle.net/1911/78733en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordcytoskeleton proteinsen_US
dc.subject.keyworddynamic instabilityen_US
dc.subject.keywordagingen_US
dc.subject.keyworddynamic processesen_US
dc.titleTheoretical Analysis of Microtubule Dynamics at All Timesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
paper.JPCB2.pdf
Size:
830.83 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Chemistry Publications