Strategic stabilization of arousal boosts sustained attention

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dc.citation.firstpage4114en_US
dc.citation.issueNumber18en_US
dc.citation.journalTitleCurrent Biologyen_US
dc.citation.lastpage4128.e6en_US
dc.citation.volumeNumber34en_US
dc.contributor.authorde Gee, Jan Willemen_US
dc.contributor.authorMridha, Zakiren_US
dc.contributor.authorHudson, Marisaen_US
dc.contributor.authorShi, Yanchenen_US
dc.contributor.authorRamsaywak, Hannahen_US
dc.contributor.authorSmith, Spenceren_US
dc.contributor.authorKarediya, Nishaden_US
dc.contributor.authorThompson, Matthewen_US
dc.contributor.authorJaspe, Kiten_US
dc.contributor.authorJiang, Hongen_US
dc.contributor.authorZhang, Wenhaoen_US
dc.contributor.authorMcGinley, Matthew J.en_US
dc.date.accessioned2024-11-20T15:52:02Zen_US
dc.date.available2024-11-20T15:52:02Zen_US
dc.date.issued2024en_US
dc.description.abstractArousal and motivation interact to profoundly influence behavior. For example, experience tells us that we have some capacity to control our arousal when appropriately motivated, such as staying awake while driving a motor vehicle. However, little is known about how arousal and motivation jointly influence decision computations, including if and how animals, such as rodents, adapt their arousal state to their needs. Here, we developed and show results from an auditory, feature-based, sustained-attention task with intermittently shifting task utility. We use pupil size to estimate arousal across a wide range of states and apply tailored signal-detection theoretic, hazard function, and accumulation-to-bound modeling approaches in a large cohort of mice. We find that pupil-linked arousal and task utility both have major impacts on multiple aspects of task performance. Although substantial arousal fluctuations persist across utility conditions, mice partially stabilize their arousal near an intermediate and optimal level when task utility is high. Behavioral analyses show that multiple elements of behavior improve during high task utility and that arousal influences some, but not all, of them. Specifically, arousal influences the likelihood and timescale of sensory evidence accumulation but not the quantity of evidence accumulated per time step while attending. In sum, the results establish specific decision-computational signatures of arousal, motivation, and their interaction in attention. So doing, we provide an experimental and analysis framework for studying arousal self-regulation in neurotypical brains and in diseases such as attention-deficit/hyperactivity disorder.en_US
dc.identifier.citationGee, J. W. de, Mridha, Z., Hudson, M., Shi, Y., Ramsaywak, H., Smith, S., Karediya, N., Thompson, M., Jaspe, K., Jiang, H., Zhang, W., & McGinley, M. J. (2024). Strategic stabilization of arousal boosts sustained attention. Current Biology, 34(18), 4114-4128.e6. https://doi.org/10.1016/j.cub.2024.07.070en_US
dc.identifier.digitalPIIS0960982224010091en_US
dc.identifier.doihttps://doi.org/10.1016/j.cub.2024.07.070en_US
dc.identifier.urihttps://hdl.handle.net/1911/118046en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial (CC BY-NC) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.subject.keywordarousalen_US
dc.subject.keywordattentionen_US
dc.subject.keywordpupilen_US
dc.subject.keywordsignal detection theoryen_US
dc.subject.keywordsurvival analysisen_US
dc.subject.keywordsensitivityen_US
dc.subject.keywordlistening efforten_US
dc.subject.keywordevidence accumulationen_US
dc.subject.keywordmotivationen_US
dc.subject.keywordtask utilityen_US
dc.titleStrategic stabilization of arousal boosts sustained attentionen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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