Expression of CXCL12 and CXCL14 during eye development in chick and mouse

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dc.citation.firstpage303en_US
dc.citation.issueNumber8en_US
dc.citation.journalTitleGene Expression Patternsen_US
dc.citation.lastpage310en_US
dc.citation.volumeNumber13en_US
dc.contributor.authorOjeda, Ana F.en_US
dc.contributor.authorMunjaal, Ravi P.en_US
dc.contributor.authorLwigale, Peter Y.en_US
dc.date.accessioned2015-07-09T20:14:49Zen_US
dc.date.available2015-07-09T20:14:49Zen_US
dc.date.issued2013en_US
dc.description.abstractVertebrate eye development is a complex multistep process coordinated by signals from the lens, optic cup and periocular mesenchyme. Although chemokines are increasingly being recognized as key players in cell migration, proliferation, and differentiation during embryonic development, their potential role during eye development has not been examined. In this study, we demonstrate by section in situ hybridization that CXCL12 and CXCL14 are expressed during ocular development. CXCL12 is expressed in the periocular mesenchyme, ocular blood vessels, retina, and eyelid mesenchyme, and its expression pattern is conserved between chick and mouse in most tissues. Expression of CXCL14 is localized in the ocular ectoderm, limbal epithelium, scleral papillae, eyelid mesenchyme, corneal keratocytes, hair follicles, and retina, and it was only conserved in the upper eyelid ectoderm of chick and mouse. The unique and non-overlapping patterns of CXCL12 and CXCL14 expression in ocular tissues suggest that these two chemokines may interact and have important functions in cell proliferation, differentiation and migration during eye development.en_US
dc.identifier.citationOjeda, Ana F., Munjaal, Ravi P. and Lwigale, Peter Y.. "Expression of CXCL12 and CXCL14 during eye development in chick and mouse." <i>Gene Expression Patterns,</i> 13, no. 8 (2013) Elsevier: 303-310. http://dx.doi.org/10.1016/j.gep.2013.05.006.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.gep.2013.05.006en_US
dc.identifier.urihttps://hdl.handle.net/1911/80868en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordcorneaen_US
dc.subject.keywordlimbal epitheliumen_US
dc.subject.keywordeyeliden_US
dc.subject.keywordnictitating membraneen_US
dc.subject.keywordscleral ossiclesen_US
dc.subject.keywordretinaen_US
dc.titleExpression of CXCL12 and CXCL14 during eye development in chick and mouseen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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