Expression of CXCL12 and CXCL14 during eye development in chick and mouse

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dc.citation.firstpage303
dc.citation.issueNumber8
dc.citation.journalTitleGene Expression Patterns
dc.citation.lastpage310
dc.citation.volumeNumber13
dc.contributor.authorOjeda, Ana F.
dc.contributor.authorMunjaal, Ravi P.
dc.contributor.authorLwigale, Peter Y.
dc.date.accessioned2015-07-09T20:14:49Z
dc.date.available2015-07-09T20:14:49Z
dc.date.issued2013
dc.description.abstractVertebrate eye development is a complex multistep process coordinated by signals from the lens, optic cup and periocular mesenchyme. Although chemokines are increasingly being recognized as key players in cell migration, proliferation, and differentiation during embryonic development, their potential role during eye development has not been examined. In this study, we demonstrate by section in situ hybridization that CXCL12 and CXCL14 are expressed during ocular development. CXCL12 is expressed in the periocular mesenchyme, ocular blood vessels, retina, and eyelid mesenchyme, and its expression pattern is conserved between chick and mouse in most tissues. Expression of CXCL14 is localized in the ocular ectoderm, limbal epithelium, scleral papillae, eyelid mesenchyme, corneal keratocytes, hair follicles, and retina, and it was only conserved in the upper eyelid ectoderm of chick and mouse. The unique and non-overlapping patterns of CXCL12 and CXCL14 expression in ocular tissues suggest that these two chemokines may interact and have important functions in cell proliferation, differentiation and migration during eye development.
dc.identifier.citationOjeda, Ana F., Munjaal, Ravi P. and Lwigale, Peter Y.. "Expression of CXCL12 and CXCL14 during eye development in chick and mouse." <i>Gene Expression Patterns,</i> 13, no. 8 (2013) Elsevier: 303-310. http://dx.doi.org/10.1016/j.gep.2013.05.006.
dc.identifier.doihttp://dx.doi.org/10.1016/j.gep.2013.05.006
dc.identifier.urihttps://hdl.handle.net/1911/80868
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.
dc.subject.keywordcornea
dc.subject.keywordlimbal epithelium
dc.subject.keywordeyelid
dc.subject.keywordnictitating membrane
dc.subject.keywordscleral ossicles
dc.subject.keywordretina
dc.titleExpression of CXCL12 and CXCL14 during eye development in chick and mouse
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpost-print
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