Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans

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dc.citation.firstpage2716
dc.citation.issueNumber12
dc.citation.journalTitleEnvironmental Toxicology and Chemistry
dc.citation.lastpage2723
dc.citation.volumeNumber33
dc.contributor.authorContreras, Elizabeth Q.
dc.contributor.authorPuppala, Hema L.
dc.contributor.authorEscalera, Gabriela
dc.contributor.authorZhong, Weiwei
dc.contributor.authorColvin, Vicki L.
dc.date.accessioned2016-01-19T19:19:42Z
dc.date.available2016-01-19T19:19:42Z
dc.date.issued2014
dc.description.abstractThe increased bioavailability of nanoparticles engineered for good dispersion in water may have biological and environmental impacts. To examine this issue, the authors assessed the biological effects in nematodes as they relate to exposure to silver nanoparticles (AgNPs) of different sizes at low (1 mg/L Ag), medium (10 mg/L Ag), and high concentrations (100 mg/L Ag). Over multiple generations, the authors found that the smallest particle, at 2 nm, had a notable impact on nematode fertility. In contrast, the largest particle, at 10 nm, significantly reduced the lifespan of parent nematodes (P0) by 28.8% and over the span of 3 generations (F1–F3). In addition, a computer vision system automatically measured the adverse effects in body length and motility, which were not size-dependent.
dc.identifier.citationContreras, Elizabeth Q., Puppala, Hema L., Escalera, Gabriela, et al.. "Size-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans." <i>Environmental Toxicology and Chemistry,</i> 33, no. 12 (2014) Wiley: 2716-2723. http://dx.doi.org/10.1002/etc.2705.
dc.identifier.doihttp://dx.doi.org/10.1002/etc.2705
dc.identifier.urihttps://hdl.handle.net/1911/87883
dc.language.isoeng
dc.publisherWiley
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
dc.subject.keywordCaenorhabditis elegans
dc.subject.keywordsilver nanoparticle
dc.subject.keywordmultigenerational
dc.subject.keywordtoxicity
dc.subject.keywordEscherichia coli
dc.titleSize-dependent impacts of silver nanoparticles on the lifespan, fertility, growth, and locomotion of Caenorhabditis elegans
dc.typeJournal article
dc.type.dcmiTexten_US
dc.type.publicationpost-print
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