Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription

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dc.citation.articleNumber111567en_US
dc.citation.issueNumber5en_US
dc.citation.journalTitleCell Reportsen_US
dc.citation.volumeNumber41en_US
dc.contributor.authorReed, Kathleen S. M.en_US
dc.contributor.authorDavis, Eric S.en_US
dc.contributor.authorBond, Marielle L.en_US
dc.contributor.authorCabrera, Alanen_US
dc.contributor.authorThulson, Elizaen_US
dc.contributor.authorQuiroga, Ivana Yoselien_US
dc.contributor.authorCassel, Shannonen_US
dc.contributor.authorWoolery, Kamisha T.en_US
dc.contributor.authorHilton, Isaacen_US
dc.contributor.authorWon, Hyejungen_US
dc.contributor.authorLove, Michael I.en_US
dc.contributor.authorPhanstiel, Douglas H.en_US
dc.date.accessioned2022-12-13T19:11:06Zen_US
dc.date.available2022-12-13T19:11:06Zen_US
dc.date.issued2022en_US
dc.description.abstractTo infer potential causal relationships between 3D chromatin structure, enhancers, and gene transcription, we mapped each feature in a genome-wide fashion across eight narrowly spaced time points of macrophage activation. Enhancers and genes connected by loops exhibit stronger correlations between histone H3K27 acetylation and expression than can be explained by genomic distance or physical proximity alone. At these looped enhancer-promoter pairs, changes in acetylation at distal enhancers precede changes in gene expression. Changes in gene expression exhibit a directional bias at differential loop anchors; gained loops are associated with increased expression of genes oriented away from the center of the loop, and lost loops are often accompanied by high levels of transcription within the loop boundaries themselves. These results are consistent with a reciprocal relationship where loops can facilitate increased transcription by connecting promoters to distal enhancers, whereas high levels of transcription can impede loop formation.en_US
dc.identifier.citationReed, Kathleen S. M., Davis, Eric S., Bond, Marielle L., et al.. "Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription." <i>Cell Reports,</i> 41, no. 5 (2022) Elsevier: https://doi.org/10.1016/j.celrep.2022.111567.en_US
dc.identifier.digital1-s2-0-S2211124722014280-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2022.111567en_US
dc.identifier.urihttps://hdl.handle.net/1911/114077en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/).en_US
dc.titleTemporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcriptionen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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