Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription

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dc.citation.articleNumber111567
dc.citation.issueNumber5
dc.citation.journalTitleCell Reports
dc.citation.volumeNumber41
dc.contributor.authorReed, Kathleen S. M.
dc.contributor.authorDavis, Eric S.
dc.contributor.authorBond, Marielle L.
dc.contributor.authorCabrera, Alan
dc.contributor.authorThulson, Eliza
dc.contributor.authorQuiroga, Ivana Yoseli
dc.contributor.authorCassel, Shannon
dc.contributor.authorWoolery, Kamisha T.
dc.contributor.authorHilton, Isaac
dc.contributor.authorWon, Hyejung
dc.contributor.authorLove, Michael I.
dc.contributor.authorPhanstiel, Douglas H.
dc.date.accessioned2022-12-13T19:11:06Z
dc.date.available2022-12-13T19:11:06Z
dc.date.issued2022
dc.description.abstractTo infer potential causal relationships between 3D chromatin structure, enhancers, and gene transcription, we mapped each feature in a genome-wide fashion across eight narrowly spaced time points of macrophage activation. Enhancers and genes connected by loops exhibit stronger correlations between histone H3K27 acetylation and expression than can be explained by genomic distance or physical proximity alone. At these looped enhancer-promoter pairs, changes in acetylation at distal enhancers precede changes in gene expression. Changes in gene expression exhibit a directional bias at differential loop anchors; gained loops are associated with increased expression of genes oriented away from the center of the loop, and lost loops are often accompanied by high levels of transcription within the loop boundaries themselves. These results are consistent with a reciprocal relationship where loops can facilitate increased transcription by connecting promoters to distal enhancers, whereas high levels of transcription can impede loop formation.
dc.identifier.citationReed, Kathleen S. M., Davis, Eric S., Bond, Marielle L., et al.. "Temporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription." <i>Cell Reports,</i> 41, no. 5 (2022) Elsevier: https://doi.org/10.1016/j.celrep.2022.111567.
dc.identifier.digital1-s2-0-S2211124722014280-main
dc.identifier.doihttps://doi.org/10.1016/j.celrep.2022.111567
dc.identifier.urihttps://hdl.handle.net/1911/114077
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/).
dc.titleTemporal analysis suggests a reciprocal relationship between 3D chromatin structure and transcription
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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