Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions

Simple item page
dc.citation.articleNumber025003
dc.citation.issueNumber2
dc.citation.journalTitleJournal of Biomedical Optics
dc.citation.volumeNumber24
dc.contributor.authorYang, Eric C.
dc.contributor.authorVohra, Imran S.
dc.contributor.authorBadaoui, Hawraa
dc.contributor.authorSchwarz, Richard A.
dc.contributor.authorCherry, Katelin D.
dc.contributor.authorQuang, Timothy
dc.contributor.authorJacob, Justin
dc.contributor.authorLang, Alex
dc.contributor.authorBass, Nancy
dc.contributor.authorRodriguez, Jessica
dc.contributor.authorWilliams, Michelle D.
dc.contributor.authorVigneswaran, Nadarajah
dc.contributor.authorGillenwater, Ann M.
dc.contributor.authorRichards-Kortum, Rebecca R.
dc.date.accessioned2021-10-19T15:35:16Z
dc.date.available2021-10-19T15:35:16Z
dc.date.issued2019
dc.description.abstractOral premalignant lesions (OPLs), such as leukoplakia, are at risk of malignant transformation to oral cancer. Clinicians can elect to biopsy OPLs and assess them for dysplasia, a marker of increased risk. However, it is challenging to decide which OPLs need a biopsy and to select a biopsy site. We developed a multimodal optical imaging system (MMIS) that fully integrates the acquisition, display, and analysis of macroscopic white-light (WL), autofluorescence (AF), and high-resolution microendoscopy (HRME) images to noninvasively evaluate OPLs. WL and AF images identify suspicious regions with high sensitivity, which are explored at higher resolution with the HRME to improve specificity. Key features include a heat map that delineates suspicious regions according to AF images, and real-time image analysis algorithms that predict pathologic diagnosis at imaged sites. Representative examples from ongoing studies of the MMIS demonstrate its ability to identify high-grade dysplasia in OPLs that are not clinically suspicious, and to avoid unnecessary biopsies of benign OPLs that are clinically suspicious. The MMIS successfully integrates optical imaging approaches (WL, AF, and HRME) at multiple scales for the noninvasive evaluation of OPLs.
dc.identifier.citationYang, Eric C., Vohra, Imran S., Badaoui, Hawraa, et al.. "Development of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions." <i>Journal of Biomedical Optics,</i> 24, no. 2 (2019) SPIE: https://doi.org/10.1117/1.JBO.24.2.025003.
dc.identifier.digital025003_1
dc.identifier.doihttps://doi.org/10.1117/1.JBO.24.2.025003
dc.identifier.urihttps://hdl.handle.net/1911/111552
dc.language.isoeng
dc.publisherSPIE
dc.rightsPublished by SPIE under a Creative Commons Attribution 4.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDevelopment of an integrated multimodal optical imaging system with real-time image analysis for the evaluation of oral premalignant lesions
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
025003_1.pdf
Size:
2.59 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications