Bioinspired electrospun dECM scaffolds guide cell growth and control the formation of myotubes

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dc.citation.articleNumbereabg4123
dc.citation.issueNumber20
dc.citation.journalTitleScience Advances
dc.citation.volumeNumber7
dc.contributor.authorSmoak, Mollie M.
dc.contributor.authorHogan, Katie J.
dc.contributor.authorGrande-Allen, K. Jane
dc.contributor.authorMikos, Antonios G.
dc.date.accessioned2021-06-10T17:36:51Z
dc.date.available2021-06-10T17:36:51Z
dc.date.issued2021
dc.description.abstractWhile skeletal muscle has a high capacity for endogenous repair in acute injuries, volumetric muscle loss can leave long-lasting or permanent structural and functional deficits to the injured muscle and surrounding tissues. With clinical treatments failing to repair lost tissue, there is a great need for a tissue-engineered therapy to promote skeletal muscle regeneration. In this study, we aim to assess the potential for electrospun decellularized skeletal muscle extracellular matrix (dECM) with tunable physicochemical properties to control mouse myoblast growth and myotube formation. The material properties as well as cell behavior – growth and differentiation – were assessed in response to modulation of crosslinking and scaffold architecture. The fabrication of a bioactive dECM-based system with tunable physicochemical properties that can control myotube formation has several applications in skeletal muscle engineering and may bring the field one step closer to developing a therapy to address these unmet clinical needs. Electrospun decellularized skeletal muscle with tunable physicochemical properties controls myoblast growth and myotube formation. Electrospun decellularized skeletal muscle with tunable physicochemical properties controls myoblast growth and myotube formation.
dc.identifier.citationSmoak, Mollie M., Hogan, Katie J., Grande-Allen, K. Jane, et al.. "Bioinspired electrospun dECM scaffolds guide cell growth and control the formation of myotubes." <i>Science Advances,</i> 7, no. 20 (2021) AAAS: https://doi.org/10.1126/sciadv.abg4123.
dc.identifier.digitaleabg4123-full
dc.identifier.doihttps://doi.org/10.1126/sciadv.abg4123
dc.identifier.urihttps://hdl.handle.net/1911/110714
dc.language.isoeng
dc.publisherAAAS
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleBioinspired electrospun dECM scaffolds guide cell growth and control the formation of myotubes
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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