Multifunctional Cu2−xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453

Hypermethylated cancer populations are hard to treat due to their enhanced chemo-resistance, characterized by aberrant methylated DNA subunits. Herein, we report on invoking response from such a cancer lineage to chemotherapy utilizing multifunctional copper telluride (Cu2−XTe) nanocubes (NCs) as photothermal and photodynamic agents, leading to significant anticancer activity. The NCs additionally possessed photoacoustic and X-ray contrast imaging abilities that could serve in image-guided therapeutic studies.

Type

Journal article

Citation

Poulose, Aby Cheruvathoor, Veeranarayanan, Srivani, Mohamed, M. Sheikh, et al.. "Multifunctional Cu2−xTe Nanocubes Mediated Combination Therapy for Multi-Drug Resistant MDA MB 453." Scientific Reports, 6, (2016) Springer Nature: http://dx.doi.org/10.1038/srep35961.

Published Version

http://dx.doi.org/10.1038/srep35961

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