Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release

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dc.citation.articleNumber291en_US
dc.citation.issueNumber4en_US
dc.citation.journalTitlePharmaceuticalsen_US
dc.citation.volumeNumber14en_US
dc.contributor.authorMamidi, Narsimhaen_US
dc.contributor.authorVelasco Delgadillo, Ramiro Manuelen_US
dc.contributor.authorBarrera, Enrique V.en_US
dc.date.accessioned2021-05-07T19:23:49Zen_US
dc.date.available2021-05-07T19:23:49Zen_US
dc.date.issued2021en_US
dc.description.abstractHerein, poly (n-(4-aminophenyl) methacrylamide)) carbon nano-onions (PAPMA-CNOs = f-CNOs) and γ-cyclodextrin/DOX-complex (CD) reinforced gelatin methacryloyl (GelMA)/f-CNOs/CD supramolecular hydrogel interfaces were fabricated using the photo-crosslinking technique. The physicochemical properties, morphology, biodegradation, and swelling properties of hydrogels were investigated. The composite hydrogels demonstrated enriched drug release under the acidic conditions (pH 4.5 = 99%, and pH 6.0 = 82%) over 18 days. Owing to the f-CNOs inclusion, GelMA/f-CNOs/CD supramolecular hydrogels presented augmented tensile strength (σult = 356.1 ± 3.4 MPa), toughness (K = 51.5 ± 0.24 Jg−1), and Young’s modulus (E = 41.8 ± 1.4 GPa). The strengthening of GelMA/f-CNOs/CD hydrogel systems indicates its good dispersion and the degree of polymer enveloping of f-CNOs within GelMA matrixes. Furthermore, the obtained hydrogels showed improved cell viability with human fibroblast cells. Nevertheless, the primed supramolecular hydrogels would pave the way for the controlled delivery systems for future drug delivery.en_US
dc.identifier.citationMamidi, Narsimha, Velasco Delgadillo, Ramiro Manuel and Barrera, Enrique V.. "Covalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Release." <i>Pharmaceuticals,</i> 14, no. 4 (2021) MDPI: https://doi.org/10.3390/ph14040291.en_US
dc.identifier.digitalpharmaceuticals-14-00291-v2en_US
dc.identifier.doihttps://doi.org/10.3390/ph14040291en_US
dc.identifier.urihttps://hdl.handle.net/1911/110497en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleCovalently Functionalized Carbon Nano-Onions Integrated Gelatin Methacryloyl Nanocomposite Hydrogel Containing γ-Cyclodextrin as Drug Carrier for High-Performance pH-Triggered Drug Releaseen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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