The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring

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dc.citation.articleNumber101198en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleCell Reports Medicineen_US
dc.citation.volumeNumber4en_US
dc.contributor.authorBatool, Syeda Maheenen_US
dc.contributor.authorYekula, Anudeepen_US
dc.contributor.authorKhanna, Prernaen_US
dc.contributor.authorHsia, Tiffaneyen_US
dc.contributor.authorGamblin, Austin S.en_US
dc.contributor.authorEkanayake, Emilen_US
dc.contributor.authorEscobedo, Ana K.en_US
dc.contributor.authorYou, Dong Gilen_US
dc.contributor.authorCastro, Cesar M.en_US
dc.contributor.authorIm, Hyungsoonen_US
dc.contributor.authorKilic, Tugbaen_US
dc.contributor.authorGarlin, Michelle Andreaen_US
dc.contributor.authorSkog, Johanen_US
dc.contributor.authorDinulescu, Daniela M.en_US
dc.contributor.authorDudley, Jonathanen_US
dc.contributor.authorAgrawal, Nishanten_US
dc.contributor.authorCheng, Jordanen_US
dc.contributor.authorAbtin, Fereidounen_US
dc.contributor.authorAberle, Denise R.en_US
dc.contributor.authorChia, Daviden_US
dc.contributor.authorElashoff, Daviden_US
dc.contributor.authorGrognan, Tristanen_US
dc.contributor.authorKrysan, Kostyantynen_US
dc.contributor.authorOh, Scott S.en_US
dc.contributor.authorStrom, Charlesen_US
dc.contributor.authorTu, Michaelen_US
dc.contributor.authorWei, Fangen_US
dc.contributor.authorXian, Rena R.en_US
dc.contributor.authorSkates, Steven J.en_US
dc.contributor.authorZhang, David Y.en_US
dc.contributor.authorTrinh, Thien_US
dc.contributor.authorWatson, Marken_US
dc.contributor.authorAft, Rebeccaen_US
dc.contributor.authorRawal, Siddarthen_US
dc.contributor.authorAgarwal, Ashutoshen_US
dc.contributor.authorKesmodel, Susan B.en_US
dc.contributor.authorYang, Changhueien_US
dc.contributor.authorShen, Chengen_US
dc.contributor.authorHochberg, Fred H.en_US
dc.contributor.authorWong, David T. W.en_US
dc.contributor.authorPatel, Abhijit A.en_US
dc.contributor.authorPapadopoulos, Nickolasen_US
dc.contributor.authorBettegowda, Chetanen_US
dc.contributor.authorCote, Richard J.en_US
dc.contributor.authorSrivastava, Sudhiren_US
dc.contributor.authorLee, Hakhoen_US
dc.contributor.authorCarter, Bob S.en_US
dc.contributor.authorBalaj, Leonoraen_US
dc.date.accessioned2024-05-08T18:56:09Zen_US
dc.date.available2024-05-08T18:56:09Zen_US
dc.date.issued2023en_US
dc.description.abstractThe emerging field of liquid biopsy stands at the forefront of novel diagnostic strategies for cancer and other diseases. Liquid biopsy allows minimally invasive molecular characterization of cancers for diagnosis, patient stratification to therapy, and longitudinal monitoring. Liquid biopsy strategies include detection and monitoring of circulating tumor cells, cell-free DNA, and extracellular vesicles. In this review, we address the current understanding and the role of existing liquid-biopsy-based modalities in cancer diagnostics and monitoring. We specifically focus on the technical and clinical challenges associated with liquid biopsy and biomarker development being addressed by the Liquid Biopsy Consortium, established through the National Cancer Institute. The Liquid Biopsy Consortium has developed new methods/assays and validated existing methods/technologies to capture and characterize tumor-derived circulating cargo, as well as addressed existing challenges and provided recommendations for advancing biomarker assays.en_US
dc.identifier.citationBatool, S. M., Yekula, A., Khanna, P., Hsia, T., Gamblin, A. S., Ekanayake, E., Escobedo, A. K., You, D. G., Castro, C. M., Im, H., Kilic, T., Garlin, M. A., Skog, J., Dinulescu, D. M., Dudley, J., Agrawal, N., Cheng, J., Abtin, F., Aberle, D. R., … Balaj, L. (2023). The Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoring. Cell Reports Medicine, 4(10), 101198. https://doi.org/10.1016/j.xcrm.2023.101198en_US
dc.identifier.digital1-s20-S2666379123003658-mainen_US
dc.identifier.doihttps://doi.org/10.1016/j.xcrm.2023.101198en_US
dc.identifier.urihttps://hdl.handle.net/1911/115659en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license. Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleThe Liquid Biopsy Consortium: Challenges and opportunities for early cancer detection and monitoringen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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