Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation

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dc.citation.journalTitleScientific Reportsen_US
dc.citation.volumeNumber6en_US
dc.contributor.authorHuq, Redwanen_US
dc.contributor.authorSamuel, Errol L.G.en_US
dc.contributor.authorSikkema, William K.A.en_US
dc.contributor.authorNilewski, Lizanne G.en_US
dc.contributor.authorLee, Thomasen_US
dc.contributor.authorTanner, Mark R.en_US
dc.contributor.authorKhan, Fatima S.en_US
dc.contributor.authorPorter, Paul C.en_US
dc.contributor.authorTajhya, Rajeev B.en_US
dc.contributor.authorPatel, Rutvik S.en_US
dc.contributor.authorInoue, Taekoen_US
dc.contributor.authorPautler, Robia G.en_US
dc.contributor.authorCorry, David B.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.authorBeeton, Christineen_US
dc.contributor.orgThe NanoCarbon Centeren_US
dc.date.accessioned2016-12-16T17:50:26Z
dc.date.available2016-12-16T17:50:26Z
dc.date.issued2016en_US
dc.description.abstractAutoimmune diseases mediated by a type of white blood cell—T lymphocytes—are currently treated using mainly broad-spectrum immunosuppressants that can lead to adverse side effects. Antioxidants represent an alternative approach for therapy of autoimmune disorders; however, dietary antioxidants are insufficient to play this role. Antioxidant carbon nanoparticles scavenge reactive oxygen species (ROS) with higher efficacy than dietary and endogenous antioxidants. Furthermore, the affinity of carbon nanoparticles for specific cell types represents an emerging tactic for cell-targeted therapy. Here, we report that nontoxic poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs), known scavengers of the ROS superoxide (O2•−) and hydroxyl radical, are preferentially internalized by T lymphocytes over other splenic immune cells. We use this selectivity to inhibit T cell activation without affecting major functions of macrophages, antigen-presenting cells that are crucial for T cell activation. We also demonstrate the in vivo effectiveness of PEG-HCCs in reducing T lymphocyte-mediated inflammation in delayed-type hypersensitivity and in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Our results suggest the preferential targeting of PEG-HCCs to T lymphocytes as a novel approach for T lymphocyte immunomodulation in autoimmune diseases without affecting other immune cells.en_US
dc.identifier.citationHuq, Redwan, Samuel, Errol L.G., Sikkema, William K.A., et al.. "Preferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulation." <i>Scientific Reports,</i> 6, (2016) Springer Nature: http://dx.doi.org/10.1038/srep33808.
dc.identifier.doihttp://dx.doi.org/10.1038/srep33808en_US
dc.identifier.urihttps://hdl.handle.net/1911/93729
dc.language.isoengen_US
dc.publisherSpringer Nature
dc.rightsThis work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the articleﾒs Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titlePreferential uptake of antioxidant carbon nanoparticles by T lymphocytes for immunomodulationen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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