Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants

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dc.citation.firstpage501en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleTrends in Biotechnologyen_US
dc.citation.lastpage505en_US
dc.citation.volumeNumber32en_US
dc.contributor.authorSamuel, Errol L.G.en_US
dc.contributor.authorDuong, MyLinh T.en_US
dc.contributor.authorBitner, Brittany R.en_US
dc.contributor.authorMarcano, Daniela C.en_US
dc.contributor.authorTour, James M.en_US
dc.contributor.authorKent, Thomas A.en_US
dc.contributor.orgSmalley Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2016-06-27T14:14:27Z
dc.date.available2016-06-27T14:14:27Z
dc.date.issued2014en_US
dc.description.abstractOxidative stress reflects an excessive accumulation of reactive oxygen species (ROS) and is a hallmark of several acute and chronic human pathologies. Although many antioxidants have been investigated, most have demonstrated poor efficacy in clinical trials. Here we discuss the limitations of current antioxidants and describe a new class of nanoparticle antioxidants, poly(ethylene glycol)-functionalized hydrophilic carbon clusters (PEG-HCCs). PEG-HCCs show high capacity to annihilate ROS such as superoxide (O2(•-)) and the hydroxyl (HO(•)) radical, show no reactivity toward the nitric oxide radical (NO(•)), and can be functionalized with targeting moieties without loss of activity. Given these properties, we propose that PEG-HCCs offer an exciting new area of study for the treatment of numerous ROS-induced human pathologies..en_US
dc.identifier.citationSamuel, Errol L.G., Duong, MyLinh T., Bitner, Brittany R., et al.. "Hydrophilic carbon clusters as therapeutic, high-capacity antioxidants." <i>Trends in Biotechnology,</i> 32, no. 10 (2014) Elsevier: 501-505. http://dx.doi.org/10.1016/j.tibtech.2014.08.005.
dc.identifier.doihttp://dx.doi.org/10.1016/j.tibtech.2014.08.005en_US
dc.identifier.urihttps://hdl.handle.net/1911/90572
dc.language.isoengen_US
dc.publisherElsevier
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Elsevier.en_US
dc.subject.keywordantioxidanten_US
dc.subject.keywordcarbon nanoparticleen_US
dc.subject.keywordoxidative stressen_US
dc.subject.keywordtraumatic brain injuryen_US
dc.titleHydrophilic carbon clusters as therapeutic, high-capacity antioxidantsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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