High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents

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dc.citation.articleNumbere02240-20
dc.citation.journalTitlemBio
dc.citation.volumeNumber12
dc.contributor.authorKang, Donghoon
dc.contributor.authorZhang, Liyang
dc.contributor.authorKirienko, Natalia V.
dc.date.accessioned2021-06-07T20:22:41Z
dc.date.available2021-06-07T20:22:41Z
dc.date.issued2021
dc.description.abstractAntimicrobial resistance is a serious medical threat, particularly given the decreasing rate of discovery of new treatments. Although attempts to find new treatments continue, it has become clear that merely discovering new antimicrobials, even if they are new classes, will be insufficient. It is essential that new strategies be aggressively pursued. Toward that end, the search for treatments that can mitigate bacterial virulence and tilt the balance of host-pathogen interactions in favor of the host has become increasingly popular. In this review, we will discuss recent progress in this field, with a special focus on synthetic small molecule antivirulents that have been identified from high-throughput screens and on treatments that are effective against the opportunistic human pathogen Pseudomonas aeruginosa.
dc.identifier.citationKang, Donghoon, Zhang, Liyang and Kirienko, Natalia V.. "High-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents." <i>mBio,</i> 12, (2021) American Society for Microbiology: https://doi.org/10.1128/mBio.02240-20.
dc.identifier.digitalmBio-2021-Kang-e02240-20
dc.identifier.doihttps://doi.org/10.1128/mBio.02240-20
dc.identifier.urihttps://hdl.handle.net/1911/110690
dc.language.isoeng
dc.publisherAmerican Society for Microbiology
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleHigh-Throughput Approaches for the Identification of Pseudomonas aeruginosa Antivirulents
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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