A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway

Simple item page
dc.citation.articleNumbereabq7116
dc.citation.issueNumber40
dc.citation.journalTitleScience Advances
dc.citation.volumeNumber8
dc.contributor.authorYuan, Bo
dc.contributor.authorZhang, Yuxiang
dc.contributor.authorZhao, Rui
dc.contributor.authorLin, Hai
dc.contributor.authorYang, Xiao
dc.contributor.authorZhu, Xiangdong
dc.contributor.authorZhang, Kai
dc.contributor.authorMikos, Antonios G.
dc.contributor.authorZhang, Xingdong
dc.date.accessioned2022-10-28T17:43:12Z
dc.date.available2022-10-28T17:43:12Z
dc.date.issued2022
dc.description.abstractOsteoinductivity of a biomaterial scaffold can notably enhance the bone healing performance. In this study, we developed a biomimetic and hierarchically porous polyetherketoneketone (PEKK) scaffold with unique osteoinductivity using a combined surface treatment strategy of a sulfonated process and a nano bone-like apatite deposition. In a beagle intramuscular model, the scaffold induced bone formation ectopically after 12-week implantation. The better bone healing ability of the scaffold than the original PEKK was also confirmed in orthotopic sites. After culturing with bone marrow–derived mesenchymal stem cells (BMSCs), the scaffold induced osteogenic differentiation of BMSCs, and the new bone formation could be mainly depending on cell signaling through adenylate cyclase 9, which activates the cyclic adenosine monophosphate/protein kinase A signaling cascade pathways. The current work reports a new osteoinductive synthetic polymeric scaffold with its detailed molecular mechanism of action for bone repair and regeneration.
dc.identifier.citationYuan, Bo, Zhang, Yuxiang, Zhao, Rui, et al.. "A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway." <i>Science Advances,</i> 8, no. 40 (2022) AAAS: https://doi.org/10.1126/sciadv.abq7116.
dc.identifier.digitalsciadv-abq7116
dc.identifier.doihttps://doi.org/10.1126/sciadv.abq7116
dc.identifier.urihttps://hdl.handle.net/1911/113778
dc.language.isoeng
dc.publisherAAAS
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleA unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
sciadv-abq7116.pdf
Size:
4.83 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications
Chemical and Biomolecular Engineering Publications