A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway

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dc.citation.articleNumbereabq7116en_US
dc.citation.issueNumber40en_US
dc.citation.journalTitleScience Advancesen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorYuan, Boen_US
dc.contributor.authorZhang, Yuxiangen_US
dc.contributor.authorZhao, Ruien_US
dc.contributor.authorLin, Haien_US
dc.contributor.authorYang, Xiaoen_US
dc.contributor.authorZhu, Xiangdongen_US
dc.contributor.authorZhang, Kaien_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.authorZhang, Xingdongen_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgChemical and Biomolecular Engineeringen_US
dc.date.accessioned2022-10-28T17:43:12Zen_US
dc.date.available2022-10-28T17:43:12Zen_US
dc.date.issued2022en_US
dc.description.abstractOsteoinductivity of a biomaterial scaffold can notably enhance the bone healing performance. In this study, we developed a biomimetic and hierarchically porous polyetherketoneketone (PEKK) scaffold with unique osteoinductivity using a combined surface treatment strategy of a sulfonated process and a nano bone-like apatite deposition. In a beagle intramuscular model, the scaffold induced bone formation ectopically after 12-week implantation. The better bone healing ability of the scaffold than the original PEKK was also confirmed in orthotopic sites. After culturing with bone marrow–derived mesenchymal stem cells (BMSCs), the scaffold induced osteogenic differentiation of BMSCs, and the new bone formation could be mainly depending on cell signaling through adenylate cyclase 9, which activates the cyclic adenosine monophosphate/protein kinase A signaling cascade pathways. The current work reports a new osteoinductive synthetic polymeric scaffold with its detailed molecular mechanism of action for bone repair and regeneration.en_US
dc.identifier.citationYuan, Bo, Zhang, Yuxiang, Zhao, Rui, et al.. "A unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathway." <i>Science Advances,</i> 8, no. 40 (2022) AAAS: https://doi.org/10.1126/sciadv.abq7116.en_US
dc.identifier.digitalsciadv-abq7116en_US
dc.identifier.doihttps://doi.org/10.1126/sciadv.abq7116en_US
dc.identifier.urihttps://hdl.handle.net/1911/113778en_US
dc.language.isoengen_US
dc.publisherAAASen_US
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.titleA unique biomimetic modification endows polyetherketoneketone scaffold with osteoinductivity by activating cAMP/PKA signaling pathwayen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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