Type II fatty acid synthesis enzymes in reverse β-oxidation

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dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorGonzalez, Ramonen_US
dc.creatorClomburg, James M.en_US
dc.creatorVick, Jacob E.en_US
dc.date.accessioned2019-11-06T16:54:26Zen_US
dc.date.available2019-11-06T16:54:26Zen_US
dc.date.filed2015-01-26en_US
dc.date.issued2019-10-22en_US
dc.description.abstractThis disclosure describes enzymes from the type II (a discrete set of enzymes) fatty acid synthesis (“FAS”) pathway that can be used in combination with thiolases to operate a functional reversal of the β-oxidation cycle. A combination of thiolases with one or more of 3-oxoacyl-[acyl-carrier-protein] reductase (FabG, others), 3-hydroxyacyl-[acp] dehydratase (FabA, FabZ, others), and enoyl-[acyl-carrier-protein] reductase (FabI, FabK, FabL, FabV, others) yields a functional reversal of the β-oxidation cycle. If only one or two enzymes are used, the remaining enzymes will be traditional beta oxidation enzymes. Once this cycle is coupled with the appropriate priming and termination pathways, the production of carboxylic acids, alcohols, hydrocarbons, amines and their α-, β-, and ω-functionalized derivatives from renewable carbon sources can be achieved.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposesen_US
dc.format.extent43en_US
dc.identifier.citationGonzalez, Ramon, Clomburg, James M. and Vick, Jacob E., "Type II fatty acid synthesis enzymes in reverse β-oxidation." Patent US10450593B2. issued 2019-10-22. Retrieved from <a href="https://hdl.handle.net/1911/107616">https://hdl.handle.net/1911/107616</a>.en_US
dc.identifier.patentIDUS10450593B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/107616en_US
dc.language.isoengen_US
dc.titleType II fatty acid synthesis enzymes in reverse β-oxidationen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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