Mechanical opening of lipid bilayers by molecular nanomachines

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dc.contributor.assigneeRice University
dc.contributor.assigneeWilliam Marsh Rice University
dc.contributor.assigneeDurham University
dc.contributor.publisherUnited States Patent and Trademark Office
dc.creatorTour, James M.
dc.creatorPal, Robert
dc.creatorGarcía, López Victor
dc.creatorNilewski, Lizanne
dc.date.accessioned2023-02-08T16:14:04Z
dc.date.available2023-02-08T16:14:04Z
dc.date.filed2021-04-16
dc.date.issued2023-01-31
dc.description.abstractEmbodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo. The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide-based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.
dc.format.extent70
dc.identifier.citationTour, James M., Pal, Robert, García, López Victor and Nilewski, Lizanne, "Mechanical opening of lipid bilayers by molecular nanomachines." Patent US11565003B2. issued 2023-01-31. Retrieved from <a href="https://hdl.handle.net/1911/114453">https://hdl.handle.net/1911/114453</a>.
dc.identifier.patentIDUS11565003B2
dc.identifier.urihttps://hdl.handle.net/1911/114453
dc.language.isoeng
dc.language.isoEnglish
dc.titleMechanical opening of lipid bilayers by molecular nanomachines
dc.typeUtility patent
dc.type.dcmiText
dc.type.genrepatents
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