Mechanical opening of lipid bilayers by molecular nanomachines

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dc.contributor.assigneeRice Universityen_US
dc.contributor.assigneeWilliam Marsh Rice Universityen_US
dc.contributor.assigneeDurham Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorTour, James M.en_US
dc.creatorPal, Roberten_US
dc.creatorGarcía, López Victoren_US
dc.creatorNilewski, Lizanneen_US
dc.date.accessioned2023-02-08T16:14:04Zen_US
dc.date.available2023-02-08T16:14:04Zen_US
dc.date.filed2021-04-16en_US
dc.date.issued2023-01-31en_US
dc.description.abstractEmbodiments of the present disclosure pertain to methods of opening a lipid bilayer by associating the lipid bilayer with a molecule that includes a moving component capable of moving (e.g., rotating) in response to an external stimulus; and exposing the molecule to an external stimulus before, during or after associating the molecule with the lipid bilayer. The exposing causes the moving component of the molecule to move and thereby open the lipid bilayer (e.g., by pore formation). The external stimuli may include an energy source, such as ultraviolet light. The opened lipid bilayer may be a component of cell membranes in vitro or in vivo. The opening of the lipid bilayer may allow for the passage of various materials (e.g., active agents, such as peptide-based drugs) through the lipid bilayer and into cells. Additional embodiments of the present disclosure pertain to the aforementioned molecules for opening lipid bilayers.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.en_US
dc.format.extent70en_US
dc.identifier.citationTour, James M., Pal, Robert, García, López Victor and Nilewski, Lizanne, "Mechanical opening of lipid bilayers by molecular nanomachines." Patent US11565003B2. issued 2023-01-31. Retrieved from <a href="https://hdl.handle.net/1911/114453">https://hdl.handle.net/1911/114453</a>.en_US
dc.identifier.patentIDUS11565003B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/114453en_US
dc.language.isoengen_US
dc.language.isoEnglishen_US
dc.titleMechanical opening of lipid bilayers by molecular nanomachinesen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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