A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

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dc.citation.firstpage706
dc.citation.journalTitleNature Biomedical Engineering
dc.citation.lastpage716
dc.citation.volumeNumber6
dc.contributor.authorChen, Joshua C.
dc.contributor.authorKan, Peter
dc.contributor.authorYu, Zhanghao
dc.contributor.authorAlrashdan, Fatima
dc.contributor.authorGarcia, Roberto
dc.contributor.authorSinger, Amanda
dc.contributor.authorLai, C.S. Edwin
dc.contributor.authorAvants, Ben
dc.contributor.authorCrosby, Scott
dc.contributor.authorLi, Zhongxi
dc.contributor.authorWang, Boshuo
dc.contributor.authorFelicella, Michelle M.
dc.contributor.authorRobledo, Ariadna
dc.contributor.authorPeterchev, Angel V.
dc.contributor.authorGoetz, Stefan M.
dc.contributor.authorHartgerink, Jeffrey D.
dc.contributor.authorSheth, Sunil A.
dc.contributor.authorYang, Kaiyuan
dc.contributor.authorRobinson, Jacob T.
dc.contributor.orgApplied Physics Program
dc.date.accessioned2022-07-06T18:09:17Z
dc.date.available2022-07-06T18:09:17Z
dc.date.issued2022
dc.description.abstractImplantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals’ sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.
dc.identifier.citationChen, Joshua C., Kan, Peter, Yu, Zhanghao, et al.. "A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves." <i>Nature Biomedical Engineering,</i> 6, (2022) Springer Nature: 706-716. https://doi.org/10.1038/s41551-022-00873-7.
dc.identifier.digitals41551-022-00873-7
dc.identifier.doihttps://doi.org/10.1038/s41551-022-00873-7
dc.identifier.urihttps://hdl.handle.net/1911/112681
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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