A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves

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dc.citation.firstpage706en_US
dc.citation.journalTitleNature Biomedical Engineeringen_US
dc.citation.lastpage716en_US
dc.citation.volumeNumber6en_US
dc.contributor.authorChen, Joshua C.en_US
dc.contributor.authorKan, Peteren_US
dc.contributor.authorYu, Zhanghaoen_US
dc.contributor.authorAlrashdan, Fatimaen_US
dc.contributor.authorGarcia, Robertoen_US
dc.contributor.authorSinger, Amandaen_US
dc.contributor.authorLai, C.S. Edwinen_US
dc.contributor.authorAvants, Benen_US
dc.contributor.authorCrosby, Scotten_US
dc.contributor.authorLi, Zhongxien_US
dc.contributor.authorWang, Boshuoen_US
dc.contributor.authorFelicella, Michelle M.en_US
dc.contributor.authorRobledo, Ariadnaen_US
dc.contributor.authorPeterchev, Angel V.en_US
dc.contributor.authorGoetz, Stefan M.en_US
dc.contributor.authorHartgerink, Jeffrey D.en_US
dc.contributor.authorSheth, Sunil A.en_US
dc.contributor.authorYang, Kaiyuanen_US
dc.contributor.authorRobinson, Jacob T.en_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgChemistryen_US
dc.contributor.orgElectrical and Computer Engineeringen_US
dc.contributor.orgApplied Physicsen_US
dc.date.accessioned2022-07-06T18:09:17Zen_US
dc.date.available2022-07-06T18:09:17Zen_US
dc.date.issued2022en_US
dc.description.abstractImplantable bioelectronic devices for the simulation of peripheral nerves could be used to treat disorders that are resistant to traditional pharmacological therapies. However, for many nerve targets, this requires invasive surgeries and the implantation of bulky devices (about a few centimetres in at least one dimension). Here we report the design and in vivo proof-of-concept testing of an endovascular wireless and battery-free millimetric implant for the stimulation of specific peripheral nerves that are difficult to reach via traditional surgeries. The device can be delivered through a percutaneous catheter and leverages magnetoelectric materials to receive data and power through tissue via a digitally programmable 1 mm × 0.8 mm system-on-a-chip. Implantation of the device directly on top of the sciatic nerve in rats and near a femoral artery in pigs (with a stimulation lead introduced into a blood vessel through a catheter) allowed for wireless stimulation of the animals’ sciatic and femoral nerves. Minimally invasive magnetoelectric implants may allow for the stimulation of nerves without the need for open surgery or the implantation of battery-powered pulse generators.en_US
dc.identifier.citationChen, Joshua C., Kan, Peter, Yu, Zhanghao, et al.. "A wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nerves." <i>Nature Biomedical Engineering,</i> 6, (2022) Springer Nature: 706-716. https://doi.org/10.1038/s41551-022-00873-7.en_US
dc.identifier.digitals41551-022-00873-7en_US
dc.identifier.doihttps://doi.org/10.1038/s41551-022-00873-7en_US
dc.identifier.urihttps://hdl.handle.net/1911/112681en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleA wireless millimetric magnetoelectric implant for the endovascular stimulation of peripheral nervesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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