Nanobomb optical coherence elastography in multilayered phantoms

Simple item page
dc.citation.firstpage5670
dc.citation.issueNumber11
dc.citation.journalTitleBiomedical Optics Express
dc.citation.lastpage5681
dc.citation.volumeNumber14
dc.contributor.authorHatami, Maryam
dc.contributor.authorNevozhay, Dmitry
dc.contributor.authorSingh, Manmohan
dc.contributor.authorSchill, Alexander
dc.contributor.authorBoerner, Paul
dc.contributor.authorAglyamov, Salavat
dc.contributor.authorSokolov, Konstantin
dc.contributor.authorLarin, Kirill V.
dc.date.accessioned2024-05-08T18:56:12Z
dc.date.available2024-05-08T18:56:12Z
dc.date.issued2023
dc.description.abstractMany tissues are composed of layered structures, and a better understanding of the changes in the layered tissue biomechanics can enable advanced guidance and monitoring of therapy. The advent of elastography using longitudinally propagating shear waves (LSWs) has created the prospect of a high-resolution assessment of depth-dependent tissue elasticity. Laser activation of liquid-to-gas phase transition of dye-loaded perfluorocarbon (PFC) nanodroplets (a.k.a., nanobombs) can produce highly localized LSWs. This study aims to leverage the potential of photoactivation of nanobombs to incudce LSWs with very high-frequency content in wave-based optical coherence elastography (OCE) to estimate the elasticity gradient with high resolution. In this work, we used multilayered tissue-mimicking phantoms to demonstrate that highly localized nanobomb (NB)-induced LSWs can discriminate depth-wise tissue elasticity gradients. The results show that the NB-induced LSWs rapidly change speed when transitioning between layers with different mechanical properties, resulting in an elasticity resolution of ∼65 µm. These results show promise for characterizing the elasticity of multilayer tissue with a fine resolution.
dc.identifier.citationHatami, M., Nevozhay, D., Singh, M., Schill, A., Boerner, P., Aglyamov, S., Sokolov, K., & Larin, K. V. (2023). Nanobomb optical coherence elastography in multilayered phantoms. Biomedical Optics Express, 14(11), 5670–5681. https://doi.org/10.1364/BOE.502576
dc.identifier.digitalboe-14-11-5670
dc.identifier.doihttps://doi.org/10.1364/BOE.502576
dc.identifier.urihttps://hdl.handle.net/1911/115691
dc.language.isoeng
dc.publisherOptica Publishing Group
dc.rightsPublished under the terms of the Optica Open Access Publishing Agreement
dc.rights.urihttps://opg.optica.org/library/license_v2.cfm#VOR-OA
dc.titleNanobomb optical coherence elastography in multilayered phantoms
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
boe-14-11-5670.pdf
Size:
6.18 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications