A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines

Simple item page
dc.citation.articleNumbere1010657en_US
dc.citation.issueNumber11en_US
dc.citation.journalTitlePLOS Computational Biologyen_US
dc.citation.volumeNumber18en_US
dc.contributor.authorGu, Xinyuen_US
dc.contributor.authorSchafer, Nicholas P.en_US
dc.contributor.authorBueno, Carlosen_US
dc.contributor.authorLu, Weien_US
dc.contributor.authorWolynes, Peter G.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2022-12-13T19:11:22Zen_US
dc.date.available2022-12-13T19:11:22Zen_US
dc.date.issued2022en_US
dc.description.abstractA prion-like RNA-binding protein, CPEB3, can regulate local translation in dendritic spines. CPEB3 monomers repress translation, whereas CPEB3 aggregates activate translation of its target mRNAs. However, the CPEB3 aggregates, as long-lasting prions, may raise the problem of unregulated translational activation. Here, we propose a computational model of the complex structure between CPEB3 RNA-binding domain (CPEB3-RBD) and small ubiquitin-like modifier protein 2 (SUMO2). Free energy calculations suggest that the allosteric effect of CPEB3-RBD/SUMO2 interaction can amplify the RNA-binding affinity of CPEB3. Combining with previous experimental observations on the SUMOylation mode of CPEB3, this model suggests an equilibrium shift of mRNA from binding to deSUMOylated CPEB3 aggregates to binding to SUMOylated CPEB3 monomers in basal synapses. This work shows how a burst of local translation in synapses can be silenced following a stimulation pulse, and explores the CPEB3/SUMO2 interplay underlying the structural change of synapses and the formation of long-term memories.en_US
dc.identifier.citationGu, Xinyu, Schafer, Nicholas P., Bueno, Carlos, et al.. "A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines." <i>PLOS Computational Biology,</i> 18, no. 11 (2022) Public Library of Science: https://doi.org/10.1371/journal.pcbi.1010657.en_US
dc.identifier.digitaljournal-pcbi-1010657en_US
dc.identifier.doihttps://doi.org/10.1371/journal.pcbi.1010657en_US
dc.identifier.urihttps://hdl.handle.net/1911/114106en_US
dc.language.isoengen_US
dc.publisherPublic Library of Scienceen_US
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleA structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spinesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
journal-pcbi-1010657.pdf
Size:
3.21 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemistry Publications