Nanofibrous Snake Venom Hemostat

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dc.citation.firstpage1300en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitleACS Biomaterials Science & Engineeringen_US
dc.citation.lastpage1305en_US
dc.citation.volumeNumber1en_US
dc.contributor.authorKumar, Vivek A.en_US
dc.contributor.authorWickremasinghe, Navindee C.en_US
dc.contributor.authorShi, Siyuen_US
dc.contributor.authorHartgerink, Jeffrey D.en_US
dc.contributor.orgBioengineeringen_US
dc.contributor.orgChemistryen_US
dc.date.accessioned2017-05-15T21:11:38Zen_US
dc.date.available2017-05-15T21:11:38Zen_US
dc.date.issued2015en_US
dc.description.abstractControlling perioperative bleeding is of critical importance to minimize hemorrhaging and fatality. Patients on anticoagulant therapy such as heparin have diminished clotting potential and are at risk for hemorrhaging. Here we describe a self-assembling nanofibrous peptide hydrogel (termed SLac) that on its own can act as a physical barrier to blood loss. SLac was loaded with snake-venom derived Batroxobin (50 μg/mL) yielding a drug-loaded hydrogel (SB50). SB50 was potentiated to enhance clotting even in the presence of heparin. In vitro evaluation of fibrin and whole blood clotting helped identify appropriate concentrations for hemostasis in vivo. Batroxobin-loaded hydrogels rapidly (within 20s) stop bleeding in both normal and heparin-treated rats in a lateral liver incision model. Compared to standard of care, Gelfoam, and investigational hemostats such as Puramatrix, only SB50 showed rapid liver incision hemostasis post surgical application. This snake venom-loaded peptide hydrogel can be applied via syringe and conforms to the wound site resulting in hemostasis. This demonstrates a facile method for surgical hemostasis even in the presence of anticoagulant therapies.en_US
dc.identifier.citationKumar, Vivek A., Wickremasinghe, Navindee C., Shi, Siyu, et al.. "Nanofibrous Snake Venom Hemostat." <i>ACS Biomaterials Science & Engineering,</i> 1, no. 12 (2015) American Chemical Society: 1300-1305. http://dx.doi.org/10.1021/acsbiomaterials.5b00356.en_US
dc.identifier.doihttp://dx.doi.org/10.1021/acsbiomaterials.5b00356en_US
dc.identifier.urihttps://hdl.handle.net/1911/94270en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordhemostasisen_US
dc.subject.keywordmultidomain peptideen_US
dc.subject.keywordself-assemblyen_US
dc.subject.keywordsupramolecular chemistryen_US
dc.titleNanofibrous Snake Venom Hemostaten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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