Beyond microtubules: The cellular environment at the endoplasmic reticulum attracts proteins to the nucleus, enabling nuclear transport

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dc.citation.articleNumber109235en_US
dc.citation.issueNumber3en_US
dc.citation.journalTitleiScienceen_US
dc.citation.volumeNumber27en_US
dc.contributor.authorChae, Seok Jooen_US
dc.contributor.authorKim, Dae Wooken_US
dc.contributor.authorIgoshin, Oleg A.en_US
dc.contributor.authorLee, Seunggyuen_US
dc.contributor.authorKim, Jae Kyoungen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2024-08-02T13:32:08Zen_US
dc.date.available2024-08-02T13:32:08Zen_US
dc.date.issued2024en_US
dc.description.abstractAll proteins are translated in the cytoplasm, yet many, including transcription factors, play vital roles in the nucleus. While previous research has concentrated on molecular motors for the transport of these proteins to the nucleus, recent observations reveal perinuclear accumulation even in the absence of an energy source, hinting at alternative mechanisms. Here, we propose that structural properties of the cellular environment, specifically the endoplasmic reticulum (ER), can promote molecular transport to the perinucleus without requiring additional energy expenditure. Specifically, physical interaction between proteins and the ER impedes their diffusion and leads to their accumulation near the nucleus. This result explains why larger proteins, more frequently interacting with the ER membrane, tend to accumulate at the perinucleus. Interestingly, such diffusion in a heterogeneous environment follows Chapman’s law rather than the popular Fick’s law. Our findings suggest a novel protein transport mechanism arising solely from characteristics of the intracellular environment.en_US
dc.identifier.citationChae, S. J., Kim, D. W., Igoshin, O. A., Lee, S., & Kim, J. K. (2024). Beyond microtubules: The cellular environment at the endoplasmic reticulum attracts proteins to the nucleus, enabling nuclear transport. iScience, 27(3). https://doi.org/10.1016/j.isci.2024.109235en_US
dc.identifier.digitalPIIS2589004224004565en_US
dc.identifier.doihttps://doi.org/10.1016/j.isci.2024.109235en_US
dc.identifier.urihttps://hdl.handle.net/1911/117560en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.titleBeyond microtubules: The cellular environment at the endoplasmic reticulum attracts proteins to the nucleus, enabling nuclear transporten_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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