Fecal Microbiota Transplantation Derived from Alzheimer’s Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controls

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dc.citation.articleNumber4476en_US
dc.citation.issueNumber9en_US
dc.citation.journalTitleInternational Journal of Molecular Sciencesen_US
dc.citation.volumeNumber23en_US
dc.contributor.authorSoriano, Sirenaen_US
dc.contributor.authorCurry, Kristenen_US
dc.contributor.authorWang, Qien_US
dc.contributor.authorChow, Elsbethen_US
dc.contributor.authorTreangen, Todd J.en_US
dc.contributor.authorVillapol, Soniaen_US
dc.date.accessioned2022-04-28T14:29:05Zen_US
dc.date.available2022-04-28T14:29:05Zen_US
dc.date.issued2022en_US
dc.description.abstractTraumatic brain injury (TBI) causes neuroinflammation and neurodegeneration, both of which increase the risk and accelerate the progression of Alzheimer’s disease (AD). The gut microbiome is an essential modulator of the immune system, impacting the brain. AD has been related with reduced diversity and alterations in the community composition of the gut microbiota. This study aimed to determine whether the gut microbiota from AD mice exacerbates neurological deficits after TBI in control mice. We prepared fecal microbiota transplants from 18 to 24 month old 3×Tg-AD (FMT-AD) and from healthy control (FMT-young) mice. FMTs were administered orally to young control C57BL/6 (wild-type, WT) mice after they underwent controlled cortical impact (CCI) injury, as a model of TBI. Then, we characterized the microbiota composition of the fecal samples by full-length 16S rRNA gene sequencing analysis. We collected the blood, brain, and gut tissues for protein and immunohistochemical analysis. Our results showed that FMT-AD administration stimulates a higher relative abundance of the genus Muribaculum and a decrease in Lactobacillus johnsonii compared to FMT-young in WT mice. Furthermore, WT mice exhibited larger lesion, increased activated microglia/macrophages, and reduced motor recovery after FMT-AD compared to FMT-young one day after TBI. In summary, we observed gut microbiota from AD mice to have a detrimental effect and aggravate the neuroinflammatory response and neurological outcomes after TBI in young WT mice.en_US
dc.identifier.citationSoriano, Sirena, Curry, Kristen, Wang, Qi, et al.. "Fecal Microbiota Transplantation Derived from Alzheimer’s Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controls." <i>International Journal of Molecular Sciences,</i> 23, no. 9 (2022) MDPI: https://doi.org/10.3390/ijms23094476.en_US
dc.identifier.digitalijms-23-04476en_US
dc.identifier.doihttps://doi.org/10.3390/ijms23094476en_US
dc.identifier.urihttps://hdl.handle.net/1911/112187en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleFecal Microbiota Transplantation Derived from Alzheimer’s Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controlsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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