Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats

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dc.citation.firstpageS632
dc.citation.issueNumberSuppl 24
dc.citation.journalTitleSurgical Neurology International
dc.citation.lastpageS636
dc.citation.volumeNumber7
dc.contributor.authorKim, C-Yoon
dc.contributor.authorSikkema, William K. A.
dc.contributor.authorHwang, In-Kyu
dc.contributor.authorOh, Hanseul
dc.contributor.authorKim, Un Jeng
dc.contributor.authorLee, Bae Hwan
dc.contributor.authorTour, James M.
dc.contributor.orgThe NanoCarbon Center
dc.date.accessioned2016-12-16T17:50:26Z
dc.date.available2016-12-16T17:50:26Z
dc.date.issued2016
dc.description.abstractBackground: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons. Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery. Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery. Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord.
dc.identifier.citationKim, C-Yoon, Sikkema, William K. A., Hwang, In-Kyu, et al.. "Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats." <i>Surgical Neurology International,</i> 7, no. Suppl 24 (2016) Surgical Neurology International: S632-S636. http://dx.doi.org/10.4103/2152-7806.190475.
dc.identifier.doihttp://dx.doi.org/10.4103/2152-7806.190475
dc.identifier.urihttps://hdl.handle.net/1911/93727
dc.language.isoeng
dc.publisherSurgical Neurology International
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
dc.rights.urihttps://creativecommons.org/licenses/by-nc-sa/3.0/us/
dc.subject.keywordCephalosomatic anastomosis
dc.subject.keywordelectrophysiology
dc.subject.keywordgraphene nanoribbons
dc.subject.keywordGEMINI
dc.subject.keywordspinal cord fusion
dc.titleSpinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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