Genotoxicity and Cytotoxicity of Cadmium Sulfide Nanomaterials to Mice: Comparison Between Nanorods and Nanodots

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dc.citation.firstpage373en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleEnvironmental Engineering Scienceen_US
dc.citation.lastpage380en_US
dc.citation.volumeNumber31en_US
dc.contributor.authorLiu, Luen_US
dc.contributor.authorSun, Meiqingen_US
dc.contributor.authorLi, Qingzhaoen_US
dc.contributor.authorZhang, Hongmeien_US
dc.contributor.authorAlvarez, Pedro J.J.en_US
dc.contributor.authorLiu, Huajieen_US
dc.contributor.authorChen, Weien_US
dc.date.accessioned2014-07-23T15:30:35Zen_US
dc.date.available2014-07-23T15:30:35Zen_US
dc.date.issued2014en_US
dc.description.abstractCadmium sulfide (CdS) nanomaterials (such as CdS nanodots or nanorods) are widely used in optical, electronic, and biological applications. Large-scale production and use of these materials will likely result in accidental and incidental releases, which raise concerns about their potential environmental and human-health impacts. Most studies on toxicity of Cd-containing nanomaterials have focused on nanodots, and the relative toxicity of Cd containing nanorods is not well understood. Here, we compared genotoxicity and cytotoxicity of CdS nanorods (30-50nm diameter, 500-1100 nm length) and cubic CdS nanodots (3-5 nm) in mice by examining total cadmium accumulation in organs, acute toxicity, DNA damage, spermatozoon viability and abnormality, kidney and liver damage, and oxidative stress. Compared with (smaller) nanodots, nanorods resulted in relatively low bioaccumulation, acute toxicity, and damage to spermatozoa and the tested organs. Differences in toxicity between CdS nanodots and nanorods could not be fully explained by differences in their metal ion (Cd2 + ) release patterns, based on control tests with mice gavaged with dissolved CdCl2 at equivalent concentrations. This underscores that toxicity of metallic nanomaterials could not be solely predicted based either on their elemental composition or on the amount of ions released before receptor intake. Particle morphology (including size) may also need to be considered.en_US
dc.identifier.citationLiu, Lu, Sun, Meiqing, Li, Qingzhao, et al.. "Genotoxicity and Cytotoxicity of Cadmium Sulfide Nanomaterials to Mice: Comparison Between Nanorods and Nanodots." <i>Environmental Engineering Science,</i> 31, no. 7 (2014) Mary Ann Liebert, Inc.: 373-380. http://dx.doi.org/10.1089/ees.2013.0417.en_US
dc.identifier.doihttp://dx.doi.org/10.1089/ees.2013.0417en_US
dc.identifier.urihttps://hdl.handle.net/1911/76257en_US
dc.language.isoengen_US
dc.publisherMary Ann Liebert, Inc.en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.subject.keywordcadmium sulfideen_US
dc.subject.keywordcytotoxicityen_US
dc.subject.keywordgenotoxicityen_US
dc.subject.keywordnanodotsen_US
dc.subject.keywordnanorodsen_US
dc.titleGenotoxicity and Cytotoxicity of Cadmium Sulfide Nanomaterials to Mice: Comparison Between Nanorods and Nanodotsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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