Synthesis of isoprenoids and derivatives

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dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorGonzalez, Ramonen_US
dc.creatorClomburg, James M.en_US
dc.creatorCheong, Seokjungen_US
dc.date.accessioned2022-02-25T16:48:25Zen_US
dc.date.available2022-02-25T16:48:25Zen_US
dc.date.filed2017-03-15en_US
dc.date.issued2021-06-29en_US
dc.description.abstractThis disclosure generally relates to the use of enzyme combinations or recombinant microbes comprising same to make isoprenoid precursors, isoprenoids and derivatives thereof including prenylated aromatic compounds. Novel metabolic pathways exploiting Claisen, aldol, and acyioin condensations are used instead of the natural mevalonate (MVA) pathway or 1-deoxy-d-xylulose 5-phosphate (DXP) pathways for generating isoprenoid precursors such as isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), and geranyl pyrophosphate (GPP). These pathways have the potential for better carbon and or energy efficiency than native pathways. Both decarboxylative and non-carboxylative condensations are utilized, enabling product synthesis from a number of different starting compounds. These condensation reactions serve as a platform for the synthesis of isoprenoid precursors when utilized in combination with a variety of metabolic pathways and enzymes for carbon rearrangement and the addition/removal of functional groups. Isoprenoid alcohols are key intermediary products for the production of isoprenoid precursors in these novel synthetic metabolic pathways.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposes.en_US
dc.format.extent205en_US
dc.identifier.citationGonzalez, Ramon, Clomburg, James M. and Cheong, Seokjung, "Synthesis of isoprenoids and derivatives." Patent US11046978B2. issued 2021-06-29. Retrieved from <a href="https://hdl.handle.net/1911/111985">https://hdl.handle.net/1911/111985</a>.en_US
dc.identifier.patentIDUS11046978B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/111985en_US
dc.language.isoengen_US
dc.language.isoEnglishen_US
dc.titleSynthesis of isoprenoids and derivativesen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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