Quantitative analysis of in vivo high-resolution microendoscopic images for the detection of neoplastic colorectal polyps

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dc.citation.articleNumber116003en_US
dc.citation.issueNumber11en_US
dc.citation.journalTitleJournal of Biomedical Opticsen_US
dc.citation.volumeNumber23en_US
dc.contributor.authorTang, Yuboen_US
dc.contributor.authorPolydorides, Alexandros D.en_US
dc.contributor.authorAnandasabapathy, Sharmilaen_US
dc.contributor.authorRichards-Kortum, Rebecca R.en_US
dc.date.accessioned2019-01-09T17:21:04Zen_US
dc.date.available2019-01-09T17:21:04Zen_US
dc.date.issued2018en_US
dc.description.abstractColonoscopy is routinely performed for colorectal cancer screening but lacks the capability to accurately characterize precursor lesions and early cancers. High-resolution microendoscopy (HRME) is a low-cost imaging tool to visualize colorectal polyps with subcellular resolution. We present a computer-aided algorithm to evaluate HRME images of colorectal polyps and classify neoplastic from benign lesions. Using histopathology as the gold standard, clinically relevant features based on luminal morphology and texture are quantified to build the classification algorithm. We demonstrate that adenomatous polyps can be identified with a sensitivity and specificity of 100% and 80% using a two-feature linear discriminant model in a pilot test set. The classification algorithm presented here offers an objective framework to detect adenomatous lesions in the colon with high accuracy and can potentially improve real-time assessment of colorectal polyps.en_US
dc.identifier.citationTang, Yubo, Polydorides, Alexandros D., Anandasabapathy, Sharmila, et al.. "Quantitative analysis of in vivo high-resolution microendoscopic images for the detection of neoplastic colorectal polyps." <i>Journal of Biomedical Optics,</i> 23, no. 11 (2018) SPIE: https://doi.org/10.1117/1.JBO.23.11.116003.en_US
dc.identifier.digital116003_1en_US
dc.identifier.doihttps://doi.org/10.1117/1.JBO.23.11.116003en_US
dc.identifier.urihttps://hdl.handle.net/1911/105014en_US
dc.language.isoengen_US
dc.publisherSPIEen_US
dc.rightsPublished by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/en_US
dc.subject.keywordadenomatous polypsen_US
dc.subject.keywordcolorectal canceren_US
dc.subject.keywordcomputer-aided diagnosisen_US
dc.subject.keywordmicroendoscopeen_US
dc.subject.keywordquantitative analysisen_US
dc.titleQuantitative analysis of in vivo high-resolution microendoscopic images for the detection of neoplastic colorectal polypsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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