Design of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification
dc.citation.firstpage | e0139449 | |
dc.citation.issueNumber | 10 | |
dc.citation.journalTitle | PLoS ONE | |
dc.citation.volumeNumber | 10 | |
dc.contributor.author | Shah, Kamal G. | |
dc.contributor.author | Guelig, Dylan | |
dc.contributor.author | Diesburg, Steven | |
dc.contributor.author | Buser, Joshua | |
dc.contributor.author | Burton, Robert | |
dc.contributor.author | LaBarre, Paul | |
dc.contributor.author | Richards-Kortum, Rebecca | |
dc.contributor.author | Weigl, Bernhard | |
dc.date.accessioned | 2016-04-01T20:24:37Z | |
dc.date.available | 2016-04-01T20:24:37Z | |
dc.date.issued | 2015 | |
dc.description.abstract | Previous chemical heater designs for isothermal nucleic acid amplification have been based on solid-liquid phase transition, but using this approach, developers have identified design challenges en route to developing a low-cost, disposable device. Here, we demonstrate the feasibility of a new heater configuration suitable for isothermal amplification in which one reactant of an exothermic reaction is a liquid-gas phase-change material, thereby eliminating the need for a separate phase-change compartment. This design offers potentially enhanced performance and energy density compared to other chemical and electric heaters. | |
dc.identifier.citation | Shah, Kamal G., Guelig, Dylan, Diesburg, Steven, et al.. "Design of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification." <i>PLoS ONE,</i> 10, no. 10 (2015) Public Library of Science: e0139449. http://dx.doi.org/10.1371/journal.pone.0139449. | |
dc.identifier.doi | http://dx.doi.org/10.1371/journal.pone.0139449 | |
dc.identifier.uri | https://hdl.handle.net/1911/88823 | |
dc.language.iso | eng | |
dc.publisher | Public Library of Science | |
dc.rights | This is an open access article distributed under the terms of the�Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.title | Design of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification | |
dc.type | Journal article | |
dc.type.dcmi | Text | |
dc.type.publication | publisher version |
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