Design of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification

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dc.citation.firstpagee0139449
dc.citation.issueNumber10
dc.citation.journalTitlePLoS ONE
dc.citation.volumeNumber10
dc.contributor.authorShah, Kamal G.
dc.contributor.authorGuelig, Dylan
dc.contributor.authorDiesburg, Steven
dc.contributor.authorBuser, Joshua
dc.contributor.authorBurton, Robert
dc.contributor.authorLaBarre, Paul
dc.contributor.authorRichards-Kortum, Rebecca
dc.contributor.authorWeigl, Bernhard
dc.date.accessioned2016-04-01T20:24:37Z
dc.date.available2016-04-01T20:24:37Z
dc.date.issued2015
dc.description.abstractPrevious chemical heater designs for isothermal nucleic acid amplification have been based on solid-liquid phase transition, but using this approach, developers have identified design challenges en route to developing a low-cost, disposable device. Here, we demonstrate the feasibility of a new heater configuration suitable for isothermal amplification in which one reactant of an exothermic reaction is a liquid-gas phase-change material, thereby eliminating the need for a separate phase-change compartment. This design offers potentially enhanced performance and energy density compared to other chemical and electric heaters.
dc.identifier.citationShah, Kamal G., Guelig, Dylan, Diesburg, Steven, et al.. "Design of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification." <i>PLoS ONE,</i> 10, no. 10 (2015) Public Library of Science: e0139449. http://dx.doi.org/10.1371/journal.pone.0139449.
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0139449
dc.identifier.urihttps://hdl.handle.net/1911/88823
dc.language.isoeng
dc.publisherPublic Library of Science
dc.rightsThis is an open access article distributed under the terms of the�Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.titleDesign of a New Type of Compact Chemical Heater for Isothermal Nucleic Acid Amplification
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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