Design and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagus

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dc.citation.articleNumber557en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleBioengineeringen_US
dc.citation.volumeNumber11en_US
dc.contributor.authorHicheri, Cheimaen_US
dc.contributor.authorAzimuddin, Ahad M.en_US
dc.contributor.authorKortum, Alexen_US
dc.contributor.authorBailey, Josephen_US
dc.contributor.authorTang, Yuboen_US
dc.contributor.authorSchwarz, Richard A.en_US
dc.contributor.authorRosen, Danielen_US
dc.contributor.authorJain, Shilpaen_US
dc.contributor.authorMansour, Nabil M.en_US
dc.contributor.authorGroth, Shawnen_US
dc.contributor.authorVasavada, Shaleenen_US
dc.contributor.authorRao, Ashwinen_US
dc.contributor.authorMaliga, Adriannaen_US
dc.contributor.authorGallego, Leslieen_US
dc.contributor.authorCarns, Jenniferen_US
dc.contributor.authorAnandasabapathy, Sharmilaen_US
dc.contributor.authorRichards-Kortum, Rebeccaen_US
dc.contributor.orgRice360 Institute for Global Health Technologiesen_US
dc.date.accessioned2024-08-07T19:15:01Zen_US
dc.date.available2024-08-07T19:15:01Zen_US
dc.date.issued2024en_US
dc.description.abstractEsophageal carcinoma is the sixth-leading cause of cancer death worldwide. A precursor to esophageal adenocarcinoma (EAC) is Barrett’s Esophagus (BE). Early-stage diagnosis and treatment of esophageal neoplasia (Barrett’s with high-grade dysplasia/intramucosal cancer) increase the five-year survival rate from 10% to 98%. BE is a global challenge; however, current endoscopes for early BE detection are costly and require extensive infrastructure for patient examination and sedation. We describe the design and evaluation of the first prototype of ScanCap, a high-resolution optical endoscopy system with a reusable, low-cost tethered capsule, designed to provide high-definition, blue-green illumination imaging for the early detection of BE in unsedated patients. The tethered capsule (12.8 mm diameter, 35.5 mm length) contains a color camera and rotating mirror and is designed to be swallowed; images are collected as the capsule is retracted manually via the tether. The tether provides electrical power and illumination at wavelengths of 415 nm and 565 nm and transmits data from the camera to a tablet. The ScanCap prototype capsule was used to image the oral mucosa in normal volunteers and ex vivo esophageal resections; images were compared to those obtained using an Olympus CV-180 endoscope. Images of superficial capillaries in intact oral mucosa were clearly visible in ScanCap images. Diagnostically relevant features of BE, including irregular Z-lines, distorted mucosa, and dilated vasculature, were clearly visible in ScanCap images of ex vivo esophageal specimens.en_US
dc.identifier.citationHicheri, C., Azimuddin, A. M., Kortum, A., Bailey, J., Tang, Y., Schwarz, R. A., Rosen, D., Jain, S., Mansour, N. M., Groth, S., Vasavada, S., Rao, A., Maliga, A., Gallego, L., Carns, J., Anandasabapathy, S., & Richards-Kortum, R. (2024). Design and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagus. Bioengineering, 11(6), Article 6. https://doi.org/10.3390/bioengineering11060557en_US
dc.identifier.digitalbioengineering-11-00557en_US
dc.identifier.doihttps://doi.org/10.3390/bioengineering11060557en_US
dc.identifier.urihttps://hdl.handle.net/1911/117605en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleDesign and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagusen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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