Design and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagus

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dc.citation.articleNumber557
dc.citation.issueNumber6
dc.citation.journalTitleBioengineering
dc.citation.volumeNumber11
dc.contributor.authorHicheri, Cheima
dc.contributor.authorAzimuddin, Ahad M.
dc.contributor.authorKortum, Alex
dc.contributor.authorBailey, Joseph
dc.contributor.authorTang, Yubo
dc.contributor.authorSchwarz, Richard A.
dc.contributor.authorRosen, Daniel
dc.contributor.authorJain, Shilpa
dc.contributor.authorMansour, Nabil M.
dc.contributor.authorGroth, Shawn
dc.contributor.authorVasavada, Shaleen
dc.contributor.authorRao, Ashwin
dc.contributor.authorMaliga, Adrianna
dc.contributor.authorGallego, Leslie
dc.contributor.authorCarns, Jennifer
dc.contributor.authorAnandasabapathy, Sharmila
dc.contributor.authorRichards-Kortum, Rebecca
dc.contributor.orgRice360 Institute for Global Health Technologies
dc.date.accessioned2024-08-07T19:15:01Z
dc.date.available2024-08-07T19:15:01Z
dc.date.issued2024
dc.description.abstractEsophageal carcinoma is the sixth-leading cause of cancer death worldwide. A precursor to esophageal adenocarcinoma (EAC) is Barrett’s Esophagus (BE). Early-stage diagnosis and treatment of esophageal neoplasia (Barrett’s with high-grade dysplasia/intramucosal cancer) increase the five-year survival rate from 10% to 98%. BE is a global challenge; however, current endoscopes for early BE detection are costly and require extensive infrastructure for patient examination and sedation. We describe the design and evaluation of the first prototype of ScanCap, a high-resolution optical endoscopy system with a reusable, low-cost tethered capsule, designed to provide high-definition, blue-green illumination imaging for the early detection of BE in unsedated patients. The tethered capsule (12.8 mm diameter, 35.5 mm length) contains a color camera and rotating mirror and is designed to be swallowed; images are collected as the capsule is retracted manually via the tether. The tether provides electrical power and illumination at wavelengths of 415 nm and 565 nm and transmits data from the camera to a tablet. The ScanCap prototype capsule was used to image the oral mucosa in normal volunteers and ex vivo esophageal resections; images were compared to those obtained using an Olympus CV-180 endoscope. Images of superficial capillaries in intact oral mucosa were clearly visible in ScanCap images. Diagnostically relevant features of BE, including irregular Z-lines, distorted mucosa, and dilated vasculature, were clearly visible in ScanCap images of ex vivo esophageal specimens.
dc.identifier.citationHicheri, C., Azimuddin, A. M., Kortum, A., Bailey, J., Tang, Y., Schwarz, R. A., Rosen, D., Jain, S., Mansour, N. M., Groth, S., Vasavada, S., Rao, A., Maliga, A., Gallego, L., Carns, J., Anandasabapathy, S., & Richards-Kortum, R. (2024). Design and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagus. Bioengineering, 11(6), Article 6. https://doi.org/10.3390/bioengineering11060557
dc.identifier.digitalbioengineering-11-00557
dc.identifier.doihttps://doi.org/10.3390/bioengineering11060557
dc.identifier.urihttps://hdl.handle.net/1911/117605
dc.language.isoeng
dc.publisherMDPI
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleDesign and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagus
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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