KAS-III free FA synthesis

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dc.contributor.assigneeRice Universityen_US
dc.contributor.publisherUnited States Patent and Trademark Officeen_US
dc.creatorSan, Ka-yiuen_US
dc.creatorZhang, Xianen_US
dc.creatorWu, Huien_US
dc.creatorWang, Danen_US
dc.date.accessioned2021-03-02T23:21:35Zen_US
dc.date.available2021-03-02T23:21:35Zen_US
dc.date.filed2016-02-22en_US
dc.date.issued2020-12-01en_US
dc.description.abstractThe present disclosure describes a genetically engineered a KASIII-independent fatty acid biosynthetic pathway that makes use of the promiscuous nature of the rest of the FAS enzymes (3-ketoacyl-ACP synthetase, 3-ketoacyl-ACP reductase, 3-hydroxyacyl ACP dehydrase, enoyl-ACP reductase) to bypass the KASIII step by providing a Co-A precursor of two or higher than two carbons (such as the four carbon butyryl-CoA) as the starting molecule. Since many CoA-based starter molecules can be supplied for the fatty acid synthesis, much more diversified products can be obtained with various carbon-chain lengths. As such, this disclosure will serve as a powerful and efficient platform to produce low to medium chain length products carrying many different functional groups.en_US
dc.digitization.specificationsThis patent information was downloaded from the US Patent and Trademark website (http://www.uspto.gov/) as image-PDFs. The PDFs were OCRed for access purposesen_US
dc.format.extent37en_US
dc.identifier.citationSan, Ka-yiu, Zhang, Xian, Wu, Hui and Wang, Dan, "KAS-III free FA synthesis." Patent US10851393B2. issued 2020-12-01. Retrieved from <a href="https://hdl.handle.net/1911/110124">https://hdl.handle.net/1911/110124</a>.en_US
dc.identifier.patentIDUS10851393B2en_US
dc.identifier.urihttps://hdl.handle.net/1911/110124en_US
dc.language.isoengen_US
dc.titleKAS-III free FA synthesisen_US
dc.typeUtility patenten_US
dc.type.dcmiTexten_US
dc.type.genrepatentsen_US
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