3D tissue-engineered model of Ewing's sarcoma

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dc.citation.firstpage155en_US
dc.citation.journalTitleAdvanced Drug Delivery Reviewsen_US
dc.citation.lastpage171en_US
dc.citation.volumeNumber79-80en_US
dc.contributor.authorLamhamedi-Cherradi, Salah-Eddineen_US
dc.contributor.authorSantoro, Marcoen_US
dc.contributor.authorRamammoorthy, Vandhanaen_US
dc.contributor.authorMenegaz, Brian A.en_US
dc.contributor.authorBartholomeusz, Geoffreyen_US
dc.contributor.authorIles, Lakesla R.en_US
dc.contributor.authorAmin, Hesham M.en_US
dc.contributor.authorLivingston, J. Andrewen_US
dc.contributor.authorMikos, Antonios G.en_US
dc.contributor.authorLudwig, Joseph A.en_US
dc.date.accessioned2015-03-19T15:07:12Zen_US
dc.date.available2015-03-19T15:07:12Zen_US
dc.date.issued2014en_US
dc.description.abstractDespite longstanding reliance upon monolayer culture for studying cancer cells, and numerous advantages from both a practical and experimental standpoint, a growing body of evidence suggests that more complex three-dimensional (3D) models are necessary to properly mimic many of the critical hallmarks associated with the oncogenesis, maintenance and spread of Ewing's sarcoma (ES), the second most common pediatric bone tumor. And as clinicians increasingly turn to biologically-targeted therapies that exert their effects not only on the tumor cells themselves, but also on the surrounding extracellular matrix, it is especially important that preclinical models evolve in parallel to reliably measure antineoplastic effects and possible mechanisms of de novo and acquired drug resistance. Herein, we highlight a number of innovative methods used to fabricate biomimetic ES tumors, encompassing both the surrounding cellular milieu and the extracellular matrix (ECM), and suggest potential applications to advance our understanding of ES biology, preclinical drug testing, and personalized medicine.en_US
dc.identifier.citationLamhamedi-Cherradi, Salah-Eddine, Santoro, Marco, Ramammoorthy, Vandhana, et al.. "3D tissue-engineered model of Ewing's sarcoma." <i>Advanced Drug Delivery Reviews,</i> 79-80, (2014) Elsevier: 155-171. http://dx.doi.org/10.1016/j.addr.2014.07.012.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.addr.2014.07.012en_US
dc.identifier.urihttps://hdl.handle.net/1911/79384en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/en_US
dc.subject.keywordEwing's sarcomaen_US
dc.subject.keywordMCTSen_US
dc.subject.keyword3Den_US
dc.subject.keywordtissue-engineeringen_US
dc.subject.keywordscaffoldsen_US
dc.subject.keywordECMen_US
dc.subject.keywordtumor modelen_US
dc.subject.keywordpreclinical testingen_US
dc.title3D tissue-engineered model of Ewing's sarcomaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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