3D tissue-engineered model of Ewing's sarcoma

Simple item page
dc.citation.firstpage155
dc.citation.journalTitleAdvanced Drug Delivery Reviews
dc.citation.lastpage171
dc.citation.volumeNumber79-80
dc.contributor.authorLamhamedi-Cherradi, Salah-Eddine
dc.contributor.authorSantoro, Marco
dc.contributor.authorRamammoorthy, Vandhana
dc.contributor.authorMenegaz, Brian A.
dc.contributor.authorBartholomeusz, Geoffrey
dc.contributor.authorIles, Lakesla R.
dc.contributor.authorAmin, Hesham M.
dc.contributor.authorLivingston, J. Andrew
dc.contributor.authorMikos, Antonios G.
dc.contributor.authorLudwig, Joseph A.
dc.date.accessioned2015-03-19T15:07:12Z
dc.date.available2015-03-19T15:07:12Z
dc.date.issued2014
dc.description.abstractDespite longstanding reliance upon monolayer culture for studying cancer cells, and numerous advantages from both a practical and experimental standpoint, a growing body of evidence suggests that more complex three-dimensional (3D) models are necessary to properly mimic many of the critical hallmarks associated with the oncogenesis, maintenance and spread of Ewing's sarcoma (ES), the second most common pediatric bone tumor. And as clinicians increasingly turn to biologically-targeted therapies that exert their effects not only on the tumor cells themselves, but also on the surrounding extracellular matrix, it is especially important that preclinical models evolve in parallel to reliably measure antineoplastic effects and possible mechanisms of de novo and acquired drug resistance. Herein, we highlight a number of innovative methods used to fabricate biomimetic ES tumors, encompassing both the surrounding cellular milieu and the extracellular matrix (ECM), and suggest potential applications to advance our understanding of ES biology, preclinical drug testing, and personalized medicine.
dc.identifier.citationLamhamedi-Cherradi, Salah-Eddine, Santoro, Marco, Ramammoorthy, Vandhana, et al.. "3D tissue-engineered model of Ewing's sarcoma." <i>Advanced Drug Delivery Reviews,</i> 79-80, (2014) Elsevier: 155-171. http://dx.doi.org/10.1016/j.addr.2014.07.012.
dc.identifier.doihttp://dx.doi.org/10.1016/j.addr.2014.07.012
dc.identifier.urihttps://hdl.handle.net/1911/79384
dc.language.isoeng
dc.publisherElsevier
dc.rightsThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject.keywordEwing's sarcoma
dc.subject.keywordMCTS
dc.subject.keyword3D
dc.subject.keywordtissue-engineering
dc.subject.keywordscaffolds
dc.subject.keywordECM
dc.subject.keywordtumor model
dc.subject.keywordpreclinical testing
dc.title3D tissue-engineered model of Ewing's sarcoma
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
3D-model.pdf
Size:
4.36 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Bioengineering Publications