Hippocampal awake replay in fear memory retrieval

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dc.citation.firstpage571en_US
dc.citation.journalTitleNature Neuroscienceen_US
dc.citation.lastpage580en_US
dc.citation.volumeNumber20en_US
dc.contributor.authorWu, Chun-Tingen_US
dc.contributor.authorHaggerty, Danielen_US
dc.contributor.authorKemere, Caleben_US
dc.contributor.authorJi, Daoyunen_US
dc.date.accessioned2017-11-15T14:12:33Zen_US
dc.date.available2017-11-15T14:12:33Zen_US
dc.date.issued2017en_US
dc.description.abstractHippocampal place cells are key to episodic memories. How these cells participate in memory retrieval remains unclear. After rats acquired a fear memory by receiving mild footshocks in a shock zone on a track, we analyzed place cells when the animals were placed on the track again and displayed an apparent memory retrieval behavior: avoidance of the shock zone. We found that place cells representing the shock zone were reactivated, despite the fact that the animals did not enter the shock zone. This reactivation occurred in ripple-associated awake replay of place cell sequences encoding the paths from the animal's current positions to the shock zone but not in place cell sequences within individual cycles of theta oscillation. The result reveals a specific place-cell pattern underlying inhibitory avoidance behavior and provides strong evidence for the involvement of awake replay in fear memory retrieval.en_US
dc.identifier.citationWu, Chun-Ting, Haggerty, Daniel, Kemere, Caleb, et al.. "Hippocampal awake replay in fear memory retrieval." <i>Nature Neuroscience,</i> 20, (2017) Springer Nature: 571-580. https://doi.org/10.1038/nn.4507.en_US
dc.identifier.digitalHippocampal_awakeen_US
dc.identifier.doihttps://doi.org/10.1038/nn.4507en_US
dc.identifier.urihttps://hdl.handle.net/1911/98815en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Springer Nature.en_US
dc.titleHippocampal awake replay in fear memory retrievalen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
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