Biotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinoma

Simple item page
dc.citation.firstpage8289en_US
dc.citation.issueNumber12en_US
dc.citation.journalTitleInternational Journal of Nanomedicineen_US
dc.citation.lastpage8307en_US
dc.citation.volumeNumber2017en_US
dc.contributor.authorLapin, Norman A.en_US
dc.contributor.authorVergara, Leoncio A.en_US
dc.contributor.authorMackeyev, Yurien_US
dc.contributor.authorNewton, Jared M.en_US
dc.contributor.authorDilliard, Sean A.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.contributor.authorCurley, Steven A.en_US
dc.contributor.authorSerda, Rita E.en_US
dc.contributor.orgThe Smalley-Curl Institute for Nanoscale Science and Technologyen_US
dc.date.accessioned2017-12-21T18:21:51Zen_US
dc.date.available2017-12-21T18:21:51Zen_US
dc.date.issued2017en_US
dc.description.abstract[60]Fullerene is a highly versatile nanoparticle (NP) platform for drug delivery to sites of pathology owing to its small size and both ease and versatility of chemical functionalization, facilitating multisite drug conjugation, drug targeting, and modulation of its physicochemical properties. The prominent and well-characterized role of the enhanced permeation and retention (EPR) effect in facilitating NP delivery to tumors motivated us to explore vascular transport kinetics of a water-soluble [60]fullerene derivatives using intravital microscopy in an immune competent murine model of breast adenocarcinoma. Herein, we present a novel local and global image analysis of vascular transport kinetics at the level of individual tumor blood vessels on the micron scale and across whole images, respectively. Similar to larger nanomaterials, [60]fullerenes displayed rapid extravasation from tumor vasculature, distinct from that in normal microvasculature. Temporal heterogeneity in fullerene delivery to tumors was observed, demonstrating the issue of nonuniform delivery beyond spatial dimensions. Trends in local region analysis of fullerene biokinetics by fluorescence quantification were in agreement with global image analysis. Further analysis of intratumoral vascular clearance rates suggested a possible enhanced penetration and retention effect of the fullerene compared to a 70 kDa vascular tracer. Overall, this study demonstrates the feasibility of tracking and quantifying the delivery kinetics and intratumoral biodistribution of fullerene-based drug delivery platforms, consistent with the EPR effect on short timescales and passive transport to tumors.en_US
dc.identifier.citationLapin, Norman A., Vergara, Leoncio A., Mackeyev, Yuri, et al.. "Biotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinoma." <i>International Journal of Nanomedicine,</i> 2017, no. 12 (2017) Dove Press: 8289-8307. https://doi.org/10.2147/IJN.S138641.en_US
dc.identifier.digitalBiotransport-kineticsen_US
dc.identifier.doihttps://doi.org/10.2147/IJN.S138641en_US
dc.identifier.urihttps://hdl.handle.net/1911/98910en_US
dc.language.isoengen_US
dc.publisherDove Pressen_US
dc.rightsThis work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License, https://creativecommons.org/licenses/by-nc/3.0/. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en_US
dc.subject.keywordbreast canceren_US
dc.subject.keyworddrug deliveryen_US
dc.subject.keywordenhanced permeation and retentionen_US
dc.subject.keywordfullereneen_US
dc.subject.keywordintravital microscopyen_US
dc.titleBiotransport kinetics and intratumoral biodistribution of malonodiserinolamide-derivatized [60]fullerene in a murine model of breast adenocarcinomaen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Biotransport-kinetics.pdf
Size:
4.21 MB
Format:
Adobe Portable Document Format
Download
Collections
Faculty Publications
Chemistry Publications