Time Based Bayesian Optimal Interval (TITE-BOIN) Design Algorithm Performance under Weibull Distribution on Simulated Phase I Clinical Trial Data

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dc.contributor.advisorYuan, Yingen_US
dc.contributor.committeeMemberVannucci, Marinaen_US
dc.contributor.committeeMemberCox, Dennisen_US
dc.contributor.committeeMemberMiller, Tomen_US
dc.creatorRogers, Donalden_US
dc.date.accessioned2016-01-25T20:30:28Zen_US
dc.date.available2016-01-25T20:30:28Zen_US
dc.date.created2015-12en_US
dc.date.issued2015-12-03en_US
dc.date.submittedDecember 2015en_US
dc.date.updated2016-01-25T20:30:28Zen_US
dc.description.abstractIn phase I clinical trials, our goal is to effectively treat the patient while minimizing the chance of exposing them to excessively toxic doses of a new drug. In order to choose the correct dose, we use an adaptive dose-finding design, the Bayesian optimal interval design (BOIN), to aid in this selection. Here, we propose evaluation of the Bayesian optimal interval design under the Weibull and uniform distribution, comparing it to a time-based algorithm of the BOIN (TITE-BOIN). Simulations show that under theWeibull distribution, standard BOIN surpasses the TITE-BOIN design in terms of recommendation of maximum tolerated dose and allocation of data. In addition, both designs under theWeibull perform better than the uniform distribution when selecting a dose. Further study of the effects of the Weibull parameters on the BOIN design and the duration of trial under the Weibull should be considered.en_US
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationRogers, Donald. "Time Based Bayesian Optimal Interval (TITE-BOIN) Design Algorithm Performance under Weibull Distribution on Simulated Phase I Clinical Trial Data." (2015) Master’s Thesis, Rice University. <a href="https://hdl.handle.net/1911/88113">https://hdl.handle.net/1911/88113</a>.en_US
dc.identifier.urihttps://hdl.handle.net/1911/88113en_US
dc.language.isoengen_US
dc.rightsCopyright is held by the author, unless otherwise indicated. Permission to reuse, publish, or reproduce the work beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.subjectBOINen_US
dc.subjectInterval Designen_US
dc.subjectBayesianen_US
dc.titleTime Based Bayesian Optimal Interval (TITE-BOIN) Design Algorithm Performance under Weibull Distribution on Simulated Phase I Clinical Trial Dataen_US
dc.typeThesisen_US
dc.type.materialTexten_US
thesis.degree.departmentStatisticsen_US
thesis.degree.disciplineEngineeringen_US
thesis.degree.grantorRice Universityen_US
thesis.degree.levelMastersen_US
thesis.degree.nameMaster of Artsen_US
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