A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses

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dc.citation.articleNumber132en_US
dc.citation.journalTitlenpj Vaccinesen_US
dc.citation.volumeNumber9en_US
dc.contributor.authorThimmiraju, Syamala Ranien_US
dc.contributor.authorAdhikari, Rakeshen_US
dc.contributor.authorRedd, JeAnna R.en_US
dc.contributor.authorVillar, Maria Joseen_US
dc.contributor.authorLee, Jungsoonen_US
dc.contributor.authorLiu, Zhuyunen_US
dc.contributor.authorChen, Yi-Linen_US
dc.contributor.authorSharma, Sumanen_US
dc.contributor.authorKaur, Amandeepen_US
dc.contributor.authorUzcategui, Nestor L.en_US
dc.contributor.authorRonca, Shannon E.en_US
dc.contributor.authorChen, Wen-Hsiangen_US
dc.contributor.authorKimata, Jason T.en_US
dc.contributor.authorZhan, Binen_US
dc.contributor.authorStrych, Ulrichen_US
dc.contributor.authorBottazzi, Maria Elenaen_US
dc.contributor.authorHotez, Peter J.en_US
dc.contributor.authorPollet, Jeroenen_US
dc.date.accessioned2024-08-07T19:15:02Zen_US
dc.date.available2024-08-07T19:15:02Zen_US
dc.date.issued2024en_US
dc.description.abstractThe development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.en_US
dc.identifier.citationThimmiraju, S. R., Adhikari, R., Redd, J. R., Villar, M. J., Lee, J., Liu, Z., Chen, Y.-L., Sharma, S., Kaur, A., Uzcategui, N. L., Ronca, S. E., Chen, W.-H., Kimata, J. T., Zhan, B., Strych, U., Bottazzi, M. E., Hotez, P. J., & Pollet, J. (2024). A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses. Npj Vaccines, 9(1), 1–5. https://doi.org/10.1038/s41541-024-00924-xen_US
dc.identifier.digitals41541-024-00924-xen_US
dc.identifier.doihttps://doi.org/10.1038/s41541-024-00924-xen_US
dc.identifier.urihttps://hdl.handle.net/1911/117615en_US
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleA trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudovirusesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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