A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses

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dc.citation.articleNumber132
dc.citation.journalTitlenpj Vaccines
dc.citation.volumeNumber9
dc.contributor.authorThimmiraju, Syamala Rani
dc.contributor.authorAdhikari, Rakesh
dc.contributor.authorRedd, JeAnna R.
dc.contributor.authorVillar, Maria Jose
dc.contributor.authorLee, Jungsoon
dc.contributor.authorLiu, Zhuyun
dc.contributor.authorChen, Yi-Lin
dc.contributor.authorSharma, Suman
dc.contributor.authorKaur, Amandeep
dc.contributor.authorUzcategui, Nestor L.
dc.contributor.authorRonca, Shannon E.
dc.contributor.authorChen, Wen-Hsiang
dc.contributor.authorKimata, Jason T.
dc.contributor.authorZhan, Bin
dc.contributor.authorStrych, Ulrich
dc.contributor.authorBottazzi, Maria Elena
dc.contributor.authorHotez, Peter J.
dc.contributor.authorPollet, Jeroen
dc.date.accessioned2024-08-07T19:15:02Z
dc.date.available2024-08-07T19:15:02Z
dc.date.issued2024
dc.description.abstractThe development of broad-spectrum coronavirus vaccines is essential to prepare for future respiratory virus pandemics. We demonstrated broad neutralization by a trivalent subunit vaccine, formulating the receptor-binding domains of SARS-CoV, MERS-CoV, and SARS-CoV-2 XBB.1.5 with Alum and CpG55.2. Vaccinated mice produced cross-neutralizing antibodies against all three human Betacoronaviruses and others currently exclusive to bats, indicating the epitope preservation of the individual antigens during co-formulation and the potential for epitope broadening.
dc.identifier.citationThimmiraju, S. R., Adhikari, R., Redd, J. R., Villar, M. J., Lee, J., Liu, Z., Chen, Y.-L., Sharma, S., Kaur, A., Uzcategui, N. L., Ronca, S. E., Chen, W.-H., Kimata, J. T., Zhan, B., Strych, U., Bottazzi, M. E., Hotez, P. J., & Pollet, J. (2024). A trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses. Npj Vaccines, 9(1), 1–5. https://doi.org/10.1038/s41541-024-00924-x
dc.identifier.digitals41541-024-00924-x
dc.identifier.doihttps://doi.org/10.1038/s41541-024-00924-x
dc.identifier.urihttps://hdl.handle.net/1911/117615
dc.language.isoeng
dc.publisherSpringer Nature
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution (CC BY) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleA trivalent protein-based pan-Betacoronavirus vaccine elicits cross-neutralizing antibodies against a panel of coronavirus pseudoviruses
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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