High-Performance Hybrid Bismuth–Carbon Nanotube Based Contrast Agent for X-ray CT Imaging

dc.citation.firstpage5709en_US
dc.citation.issueNumber7en_US
dc.citation.journalTitleACS Applied Materials & Interfacesen_US
dc.citation.lastpage5716en_US
dc.citation.volumeNumber9en_US
dc.contributor.authorHernández-Rivera, Mayraen_US
dc.contributor.authorKumar, Ishen_US
dc.contributor.authorCho, Stephen Y.en_US
dc.contributor.authorCheong, Benjamin Y.en_US
dc.contributor.authorPulikkathara, Merlyn X.en_US
dc.contributor.authorMoghaddam, Sakineh E.en_US
dc.contributor.authorWhitmire, Kenton H.en_US
dc.contributor.authorWilson, Lon J.en_US
dc.date.accessioned2017-08-01T16:54:56Z
dc.date.available2017-08-01T16:54:56Z
dc.date.issued2017en_US
dc.description.abstractCarbon nanotubes (CNTs) have been used for a plethora of biomedical applications, including their use as delivery vehicles for drugs, imaging agents, proteins, DNA, and other materials. Here, we describe the synthesis and characterization of a new CNT-based contrast agent (CA) for X-ray computed tomography (CT) imaging. The CA is a hybrid material derived from ultrashort single-walled carbon nanotubes (20–80 nm long, US-tubes) and Bi(III) oxo-salicylate clusters with four Bi(III) ions per cluster (Bi4C). The element bismuth was chosen over iodine, which is the conventional element used for CT CAs in the clinic today due to its high X-ray attenuation capability and its low toxicity, which makes bismuth a more-promising element for new CT CA design. The new CA contains 20% by weight bismuth with no detectable release of bismuth after a 48 h challenge by various biological media at 37 °C, demonstrating the presence of a strong interaction between the two components of the hybrid material. The performance of the new Bi4C@US-tubes solid material as a CT CA has been assessed using a clinical scanner and found to possess an X-ray attenuation ability of >2000 Hounsfield units (HU).en_US
dc.identifier.citationHernández-Rivera, Mayra, Kumar, Ish, Cho, Stephen Y., et al.. "High-Performance Hybrid Bismuth–Carbon Nanotube Based Contrast Agent for X-ray CT Imaging." <i>ACS Applied Materials & Interfaces,</i> 9, no. 7 (2017) American Chemical Society: 5709-5716. https://doi.org/10.1021/acsami.6b12768.
dc.identifier.doihttps://doi.org/10.1021/acsami.6b12768en_US
dc.identifier.urihttps://hdl.handle.net/1911/96033
dc.language.isoengen_US
dc.publisherAmerican Chemical Society
dc.rightsThis is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society.en_US
dc.subject.keywordcarbon nanotubesen_US
dc.subject.keywordbismuthen_US
dc.subject.keywordX-ray CTen_US
dc.subject.keywordradiocontrast agenten_US
dc.titleHigh-Performance Hybrid Bismuth–Carbon Nanotube Based Contrast Agent for X-ray CT Imagingen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpost-printen_US
Files
Original bundle
Now showing 1 - 2 of 2
Loading...
Thumbnail Image
Name:
Revised-Bi4US.pdf
Size:
1.37 MB
Format:
Adobe Portable Document Format
Description:
Loading...
Thumbnail Image
Name:
Supplemental-information.pdf
Size:
752.56 KB
Format:
Adobe Portable Document Format
Description:
Supplemental Information