Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility

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dc.citation.firstpage2513
dc.citation.issueNumber10
dc.citation.journalTitleThe Journal of Physical Chemistry B
dc.citation.lastpage2520
dc.citation.volumeNumber125
dc.contributor.authorFreiberger, Maria I.
dc.contributor.authorWolynes, Peter G.
dc.contributor.authorFerreiro, Diego U.
dc.contributor.authorFuxreiter, Monika
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2021-04-21T15:46:19Z
dc.date.available2021-04-21T15:46:19Z
dc.date.issued2021
dc.description.abstractDisordered proteins frequently serve as interaction hubs involving a constrained variety of partners. Complexes with different partners frequently exhibit distinct binding modes, involving regions that remain disordered in the bound state. While the conformational properties of disordered proteins are well-characterized in their free states, less is known about the molecular mechanisms by which specificity can be achieved not with one but with multiple partners. Using the energy landscape theory concept of protein frustration, we demonstrate that complexes of disordered proteins exhibit a high degree of local frustration, especically at the binding interface. These suboptimal interactions lead to the possibility of multiple bound substates, each displaying distinct frustration patterns, which are differently populated in complexes with different partners. These results explain how specificity of disordered proteins can be achieved without a single common bound conformation and how the confliict between different interactions can be used to control the binding to multiple partners.
dc.identifier.citationFreiberger, Maria I., Wolynes, Peter G., Ferreiro, Diego U., et al.. "Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility." <i>The Journal of Physical Chemistry B,</i> 125, no. 10 (2021) American Chemical Society: 2513-2520. https://doi.org/10.1021/acs.jpcb.0c11068.
dc.identifier.digitalacs-jpcb-0c11068
dc.identifier.doihttps://doi.org/10.1021/acs.jpcb.0c11068
dc.identifier.urihttps://hdl.handle.net/1911/110299
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution License
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.titleFrustration in Fuzzy Protein Complexes Leads to Interaction Versatility
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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