Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility

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dc.citation.firstpage2513en_US
dc.citation.issueNumber10en_US
dc.citation.journalTitleThe Journal of Physical Chemistry Ben_US
dc.citation.lastpage2520en_US
dc.citation.volumeNumber125en_US
dc.contributor.authorFreiberger, Maria I.en_US
dc.contributor.authorWolynes, Peter G.en_US
dc.contributor.authorFerreiro, Diego U.en_US
dc.contributor.authorFuxreiter, Monikaen_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2021-04-21T15:46:19Zen_US
dc.date.available2021-04-21T15:46:19Zen_US
dc.date.issued2021en_US
dc.description.abstractDisordered proteins frequently serve as interaction hubs involving a constrained variety of partners. Complexes with different partners frequently exhibit distinct binding modes, involving regions that remain disordered in the bound state. While the conformational properties of disordered proteins are well-characterized in their free states, less is known about the molecular mechanisms by which specificity can be achieved not with one but with multiple partners. Using the energy landscape theory concept of protein frustration, we demonstrate that complexes of disordered proteins exhibit a high degree of local frustration, especically at the binding interface. These suboptimal interactions lead to the possibility of multiple bound substates, each displaying distinct frustration patterns, which are differently populated in complexes with different partners. These results explain how specificity of disordered proteins can be achieved without a single common bound conformation and how the confliict between different interactions can be used to control the binding to multiple partners.en_US
dc.identifier.citationFreiberger, Maria I., Wolynes, Peter G., Ferreiro, Diego U., et al.. "Frustration in Fuzzy Protein Complexes Leads to Interaction Versatility." <i>The Journal of Physical Chemistry B,</i> 125, no. 10 (2021) American Chemical Society: 2513-2520. https://doi.org/10.1021/acs.jpcb.0c11068.en_US
dc.identifier.digitalacs-jpcb-0c11068en_US
dc.identifier.doihttps://doi.org/10.1021/acs.jpcb.0c11068en_US
dc.identifier.urihttps://hdl.handle.net/1911/110299en_US
dc.language.isoengen_US
dc.publisherAmerican Chemical Societyen_US
dc.rightsThis article is distributed under the terms of the Creative Commons Attribution Licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.titleFrustration in Fuzzy Protein Complexes Leads to Interaction Versatilityen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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