Photopatterning of conductive hydrogels which exhibit tissue-like properties

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dc.citation.firstpage10272en_US
dc.citation.issueNumber40en_US
dc.citation.journalTitleJournal of Materials Chemistry Ben_US
dc.citation.lastpage10284en_US
dc.citation.volumeNumber12en_US
dc.contributor.authorSifringer, Léoen_US
dc.contributor.authorWindt, Lina Deen_US
dc.contributor.authorBernhard, Stéphaneen_US
dc.contributor.authorAmos, Giuliaen_US
dc.contributor.authorClément, Blandineen_US
dc.contributor.authorDuru, Jensen_US
dc.contributor.authorTibbitt, Mark W.en_US
dc.contributor.authorTringides, Christina M.en_US
dc.date.accessioned2024-11-20T15:52:03Zen_US
dc.date.available2024-11-20T15:52:03Zen_US
dc.date.issued2024en_US
dc.description.abstractHydrogels are three-dimensional, highly tunable material systems that can match the properties of extracellular matrices. In addition to being widely used to grow and modulate cell behavior, hydrogels can be made conductive to further modulate electrically active cells, such as neurons, and even incorporated into multielectrode arrays to interface with tissues. To enable conductive hydrogels, graphene flakes can be mechanically suspended into a hydrogel precursor. The conductivity of the hydrogel can be increased by increasing the weight percentage of graphene flakes in the precursor while maintaining the mechanical properties of the formed gel similar to the properties of neural tissue. By using a photocrosslinkable hydrogel matrix, such as gelatin methacrylate, with a photoabsorber, the conductive precursor solutions can be crosslinked into predefined complex patterns. Finally, the formulations can be used to support the growth of sensory neurons, derived from human induced pluripotent stem cells, for more than 7 weeks while the neurons remain viable. These scaffolds can be patterned into components of multielectrode arrays, to enable ultrasoft electrodes with tissue-matched properties for further interactions, both in vitro and in vivo, with the nervous systems.en_US
dc.identifier.citationSifringer, L., Windt, L. D., Bernhard, S., Amos, G., Clément, B., Duru, J., W. Tibbitt, M., & M. Tringides, C. (2024). Photopatterning of conductive hydrogels which exhibit tissue-like properties. Journal of Materials Chemistry B, 12(40), 10272–10284. https://doi.org/10.1039/D4TB00807Cen_US
dc.identifier.digitald4tb00807cen_US
dc.identifier.doihttps://doi.org/10.1039/D4TB00807Cen_US
dc.identifier.urihttps://hdl.handle.net/1911/118053en_US
dc.language.isoengen_US
dc.publisherRoyal Society of Chemistryen_US
dc.rightsExcept where otherwise noted, this work is licensed under a Creative Commons Attribution-NonCommercial (CC BY-NC) license.  Permission to reuse, publish, or reproduce the work beyond the terms of the license or beyond the bounds of fair use or other exemptions to copyright law must be obtained from the copyright holder.en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en_US
dc.titlePhotopatterning of conductive hydrogels which exhibit tissue-like propertiesen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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