The Australian dingo is an early offshoot of modern breed dogs

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dc.citation.articleNumbereabm5944en_US
dc.citation.issueNumber16en_US
dc.citation.journalTitleScience Advancesen_US
dc.citation.volumeNumber8en_US
dc.contributor.authorField, Matt A.en_US
dc.contributor.authorYadav, Sonuen_US
dc.contributor.authorDudchenko, Olgaen_US
dc.contributor.authorEsvaran, Meeraen_US
dc.contributor.authorRosen, Benjamin D.en_US
dc.contributor.authorSkvortsova, Kseniaen_US
dc.contributor.authorEdwards, Richard J.en_US
dc.contributor.authorKeilwagen, Jensen_US
dc.contributor.authorCochran, Blake J.en_US
dc.contributor.authorManandhar, Bikashen_US
dc.contributor.authorBustamante, Soniaen_US
dc.contributor.authorRasmussen, Jacob Agerboen_US
dc.contributor.authorMelvin, Richard G.en_US
dc.contributor.authorChernoff, Barryen_US
dc.contributor.authorOmer, Arinaen_US
dc.contributor.authorColaric, Zaneen_US
dc.contributor.authorChan, Eva K. F.en_US
dc.contributor.authorMinoche, Andre E.en_US
dc.contributor.authorSmith, Timothy P. L.en_US
dc.contributor.authorGilbert, M. Thomas P.en_US
dc.contributor.authorBogdanovic, Ozrenen_US
dc.contributor.authorZammit, Robert A.en_US
dc.contributor.authorThomas, Torstenen_US
dc.contributor.authorAiden, Erez L.en_US
dc.contributor.authorBallard, J. William O.en_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2022-05-25T17:37:48Zen_US
dc.date.available2022-05-25T17:37:48Zen_US
dc.date.issued2022en_US
dc.description.abstractDogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.en_US
dc.identifier.citationField, Matt A., Yadav, Sonu, Dudchenko, Olga, et al.. "The Australian dingo is an early offshoot of modern breed dogs." <i>Science Advances,</i> 8, no. 16 (2022) AAAS: https://doi.org/10.1126/sciadv.abm5944.en_US
dc.identifier.digitalsciadv-abm5944en_US
dc.identifier.doihttps://doi.org/10.1126/sciadv.abm5944en_US
dc.identifier.urihttps://hdl.handle.net/1911/112426en_US
dc.language.isoengen_US
dc.publisherAAASen_US
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).en_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.titleThe Australian dingo is an early offshoot of modern breed dogsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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