The Australian dingo is an early offshoot of modern breed dogs

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dc.citation.articleNumbereabm5944
dc.citation.issueNumber16
dc.citation.journalTitleScience Advances
dc.citation.volumeNumber8
dc.contributor.authorField, Matt A.
dc.contributor.authorYadav, Sonu
dc.contributor.authorDudchenko, Olga
dc.contributor.authorEsvaran, Meera
dc.contributor.authorRosen, Benjamin D.
dc.contributor.authorSkvortsova, Ksenia
dc.contributor.authorEdwards, Richard J.
dc.contributor.authorKeilwagen, Jens
dc.contributor.authorCochran, Blake J.
dc.contributor.authorManandhar, Bikash
dc.contributor.authorBustamante, Sonia
dc.contributor.authorRasmussen, Jacob Agerbo
dc.contributor.authorMelvin, Richard G.
dc.contributor.authorChernoff, Barry
dc.contributor.authorOmer, Arina
dc.contributor.authorColaric, Zane
dc.contributor.authorChan, Eva K. F.
dc.contributor.authorMinoche, Andre E.
dc.contributor.authorSmith, Timothy P. L.
dc.contributor.authorGilbert, M. Thomas P.
dc.contributor.authorBogdanovic, Ozren
dc.contributor.authorZammit, Robert A.
dc.contributor.authorThomas, Torsten
dc.contributor.authorAiden, Erez L.
dc.contributor.authorBallard, J. William O.
dc.contributor.orgCenter for Theoretical Biological Physics
dc.date.accessioned2022-05-25T17:37:48Z
dc.date.available2022-05-25T17:37:48Z
dc.date.issued2022
dc.description.abstractDogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.
dc.identifier.citationField, Matt A., Yadav, Sonu, Dudchenko, Olga, et al.. "The Australian dingo is an early offshoot of modern breed dogs." <i>Science Advances,</i> 8, no. 16 (2022) AAAS: https://doi.org/10.1126/sciadv.abm5944.
dc.identifier.digitalsciadv-abm5944
dc.identifier.doihttps://doi.org/10.1126/sciadv.abm5944
dc.identifier.urihttps://hdl.handle.net/1911/112426
dc.language.isoeng
dc.publisherAAAS
dc.rightsDistributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.titleThe Australian dingo is an early offshoot of modern breed dogs
dc.typeJournal article
dc.type.dcmiText
dc.type.publicationpublisher version
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