Properties of cooperatively induced phases in sensing models

Simple item page
dc.citation.firstpage52707en_US
dc.citation.issueNumber5en_US
dc.citation.journalTitlePhysical Review Een_US
dc.citation.volumeNumber91en_US
dc.contributor.authorSevier, Stuart A.en_US
dc.contributor.authorLevine, Herberten_US
dc.contributor.orgCenter for Theoretical Biological Physicsen_US
dc.date.accessioned2016-06-10T19:01:57Zen_US
dc.date.available2016-06-10T19:01:57Zen_US
dc.date.issued2015en_US
dc.description.abstractA large number of eukaryotic cells are able to directly detect external chemical gradients with great accuracy and the ultimate limit to their sensitivity has been a topic of debate for many years. Previous work has been done to understand many aspects of this process but little attention has been paid to the possibility of emergent sensing states. Here we examine how cooperation between sensors existing in a two-dimensional network, as they do on the cell's surface, can both enhance and fundamentally alter the response of the cell to a spatially varying signal. We show that weakly interacting sensors linearly amplify the cell's response to an external gradient while a network of strongly interacting sensors form a collective nonlinear response with two separate domains of active and inactive sensors forming what have called a “1/2-state.” In our analysis we examine the cell's ability to sense the direction of a signal and pay special attention to the substantially different behavior realized in the strongly interacting regime.en_US
dc.identifier.citationSevier, Stuart A. and Levine, Herbert. "Properties of cooperatively induced phases in sensing models." <i>Physical Review E,</i> 91, no. 5 (2015) American Physical Society: 052707. http://dx.doi.org/10.1103/PhysRevE.91.052707.en_US
dc.identifier.doihttp://dx.doi.org/10.1103/PhysRevE.91.052707en_US
dc.identifier.urihttps://hdl.handle.net/1911/90492en_US
dc.language.isoengen_US
dc.publisherAmerican Physical Societyen_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.titleProperties of cooperatively induced phases in sensing modelsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
PhysRevE.91.052707.pdf
Size:
620.35 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Faculty Publications
Bioengineering Publications