T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients

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dc.citation.firstpage338en_US
dc.citation.issueNumber6en_US
dc.citation.journalTitleGenomics Proteomics Bioinformaticsen_US
dc.citation.lastpage348en_US
dc.citation.volumeNumber14en_US
dc.contributor.authorTong, Yinen_US
dc.contributor.authorLi, Zhoufangen_US
dc.contributor.authorZhang, Huaen_US
dc.contributor.authorXia, Ligangen_US
dc.contributor.authorZhang, Mengen_US
dc.contributor.authorXu, Yingen_US
dc.contributor.authorWang, Zhanhuien_US
dc.contributor.authorDeem, Michael W.en_US
dc.contributor.authorSun, Xiaojuanen_US
dc.contributor.authorHe, Jiankuien_US
dc.date.accessioned2017-01-30T17:29:31Zen_US
dc.date.available2017-01-30T17:29:31Zen_US
dc.date.issued2016en_US
dc.description.abstractType 1 diabetes mellitus (T1D) is an immune-mediated disease. The autoreactive T cells in T1D patients attack and destroy their own pancreatic cells. In order to systematically investigate the potential autoreactive T cell receptors (TCRs), we used a high-throughput immune repertoire sequencing technique to profile the spectrum of TCRs in individual T1D patients and controls. We sequenced the T cell repertoire of nine T1D patients, four type 2 diabetes (T2D) patients, and six nondiabetic controls. The diversity of the T cell repertoire in T1D patients was significantly decreased in comparison with T2D patients (P = 7.0E−08 for CD4+ T cells, P = 1.4E−04 for CD8+ T cells) and nondiabetic controls (P = 2.7E−09 for CD4+ T cells, P = 7.6E−06 for CD8+ T cells). Moreover, T1D patients had significantly more highly-expanded T cell clones than T2D patients (P = 5.2E−06 for CD4+ T cells, P = 1.9E−07 for CD8+ T cells) and nondiabetic controls (P = 1.7E−07 for CD4+ T cells, P = 3.3E−03 for CD8+ T cells). Furthermore, we identified a group of highly-expanded T cell receptor clones that are shared by more than two T1D patients. Although further validation in larger cohorts is needed, our data suggest that T cell receptor diversity measurements may become a valuable tool in investigating diabetes, such as using the diversity as an index to distinguish different types of diabetes.en_US
dc.identifier.citationTong, Yin, Li, Zhoufang, Zhang, Hua, et al.. "T Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patients." <i>Genomics Proteomics Bioinformatics,</i> 14, no. 6 (2016) Elsevier: 338-348. http://dx.doi.org/10.1016/j.gpb.2016.10.003.en_US
dc.identifier.doihttp://dx.doi.org/10.1016/j.gpb.2016.10.003en_US
dc.identifier.urihttps://hdl.handle.net/1911/93806en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsThis is an open access article under the Creative Commons CC BY license.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subject.keyworddiversityen_US
dc.subject.keywordhigh-throughput sequencingen_US
dc.subject.keywordimmune repertoireen_US
dc.subject.keywordT cell receptoren_US
dc.subject.keywordType 1 diabetesen_US
dc.titleT Cell Repertoire Diversity Is Decreased in Type 1 Diabetes Patientsen_US
dc.typeJournal articleen_US
dc.type.dcmiTexten_US
dc.type.publicationpublisher versionen_US
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